| 1 | Mon Nov 3 | vs Cleveland St | W91-88 | 1-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 2 | Thu Nov 6 | vs Mercyhurst | L65-73 | 1-1 | .500 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 3 | Sun Nov 9 | vs North Texas | L62-64 | 1-2 | .333 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 4 | Thu Nov 13 | at Wichita St | L74-95 | 1-3 | .250 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 5 | Sun Nov 16 | vs Colorado St | L67-80 | 1-4 | .200 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 6 | Fri Nov 21 | vs N Illinois | L59-76 | 1-5 | .167 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 7 | Tue Nov 25 | vs Northern Iowa | L51-72 | 1-6 | .143 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 8 | Wed Nov 26 | vs San Jose St | L51-63 | 1-7 | .125 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 9 | Tue Dec 2 | vs C Michigan | W83-72 | 2-7 | .222 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 10 | Sat Dec 6 | vs Princeton | W73-68 | 3-7 | .300 | - | USA Net | Joseph J. Gentile Arena · Chicago, IL |
| 11 | Sun Dec 14 | vs Chicago St | L75-84 | 3-8 | .273 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 12 | Wed Dec 17 | at San Francisco | L71-85 | 3-9 | .250 | - | ESPN+ | Chase Center · San Francisco, CA |
| 13 | Sat Dec 20 | at Santa Clara | W80-78 | 4-9 | .308 | - | | Leavey Center · Santa Clara, CA |
| 14 | Wed Dec 31 | at Rhode Island | W61-57 | 5-9 | .357 | - | ESPN+ | Ryan Center · Kingston, RI |
| 15 | Sat Jan 3 | vs Dayton | L68-70 | 5-10 | .333 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 16 | Wed Jan 7 | vs Davidson | L64-79 | 5-11 | .313 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 17 | Sat Jan 10 | at G Washington | L66-101 | 5-12 | .294 | - | CBSSN | Charles E. Smith Center · Washington, D.C. |
| 18 | Tue Jan 13 | vs George Mason | L74-82 | 5-13 | .278 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 19 | Fri Jan 16 | atDayton | L51-78 | 5-14 | .263 | - | ESPN2 | UD Arena · Dayton, OH |
| 20 | Tue Jan 20 | at St Bonaventure | L70-84 | 5-15 | .250 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 21 | Sat Jan 24 | vs Duquesne | L59-71 | 5-16 | .238 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Tue Jan 27 | vs Saint Joseph's | L64-85 | 5-17 | .227 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 23 | Fri Jan 30 | at VCU | L75-89 | 5-18 | .217 | - | ESPN2 | Stuart C. Siegel Center · Richmond, VA |
| 24 | Tue Feb 3 | vs La Salle | W71-61 | 6-18 | .250 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 25 | Fri Feb 6 | atDavidson | L64-84 | 6-19 | .240 | - | CBSSN | John M. Belk Arena · Davidson, NC |
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