| 1 | Mon Nov 3 | vs Appalachian St | W82-66 | 1-0 | 1.000 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 2 | Sat Nov 8 | at Bradley | L54-85 | 1-1 | .500 | - | ESPN+ | Carver Arena · Peoria, IL |
| 3 | Thu Nov 13 | at South Alabama | L64-66 | 1-2 | .333 | - | YouTube | Mitchell Center · Mobile, AL |
| 4 | Fri Nov 14 | at Coppin St | W82-59 | 2-2 | .500 | - | YouTube | Physical Education Complex · Baltimore, MD |
| 5 | Thu Nov 20 | vs N Kentucky | L66-90 | 2-3 | .400 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 6 | Sat Nov 22 | at Marquette | L71-85 | 2-4 | .333 | - | truTV | Fiserv Forum · Milwaukee, WI |
| 7 | Tue Nov 25 | vs TBD | W112-67 | 3-4 | .429 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 8 | Tue Dec 2 | at Loyola Chicago | L72-83 | 3-5 | .375 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 9 | Sun Dec 7 | at Saint Louis | L65-107 | 3-6 | .333 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 10 | Sat Dec 13 | at Stony Brook | L55-78 | 3-7 | .300 | - | | Island FCU Arena · Stony Brook, NY |
| 11 | Wed Dec 17 | vsTBD | W85-65 | 4-7 | .364 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 12 | Sat Dec 20 | at N Illinois | L73-74 | 4-8 | .333 | - | ESPN+ | NIU Convocation Center · Dekalb, IL |
| 13 | Mon Dec 22 | at Wisconsin | L61-88 | 4-9 | .308 | - | BTN | Kohl Center · Madison, WI |
| 14 | Tue Dec 30 | vs Ohio | L64-80 | 4-10 | .286 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 15 | Sat Jan 3 | vs Toledo | L75-78 | 4-11 | .267 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 16 | Tue Jan 6 | at Akron | L69-82 | 4-12 | .250 | - | ESPN+ | James A. Rhodes Arena · Akron, OH |
| 17 | Sat Jan 10 | vs Kent State | W87-85 | 5-12 | .294 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 18 | Tue Jan 13 | at Miami OH | L61-100 | 5-13 | .278 | - | ESPN+ | Millett Hall · Oxford, OH |
| 19 | Tue Jan 20 | vs Ball State | L67-68 | 5-14 | .263 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 20 | Sat Jan 24 | at W Michigan | L65-77 | 5-15 | .250 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 21 | Tue Jan 27 | vs E Michigan | W100-65 | 6-15 | .286 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 22 | Sat Jan 31 | vs Bowling Green | W62-59 | 7-15 | .318 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 23 | Tue Feb 3 | at UMass | L89-95 | 7-16 | .304 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 24 | Sat Feb 7 | at Louisiana | L80-85 | 7-17 | .292 | - | ESPN+ | Cajundome · Lafayette, LA |
Buffalo