| 1 | Mon Nov 3 | vs SE Missouri St | W92-67 | 1-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 2 | Thu Nov 6 | vs Chicago St | W108-86 | 2-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 3 | Mon Nov 10 | vs Lindenwood | W109-66 | 3-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 4 | Sat Nov 15 | vs Grand Canyon | W78-64 | 4-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 5 | Fri Nov 21 | vs Purdue FW | W91-60 | 5-0 | 1.000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 6 | Thu Nov 27 | vs Santa Clara | W71-70 | 6-0 | 1.000 | - | CBSSN | Chaifetz Arena · St. Louis, MO |
| 7 | Fri Nov 28 | vs Stanford | L77-78 | 6-1 | .857 | - | truTV | Chaifetz Arena · St. Louis, MO |
| 8 | Tue Dec 2 | at LMU | W91-70 | 7-1 | .875 | - | ESPN+ | Gersten Pavilion · Los Angeles, CA |
| 9 | Sun Dec 7 | vs C Michigan | W107-65 | 8-1 | .889 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 10 | Sat Dec 13 | vs San Francisco | W85-75 | 9-1 | .900 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 11 | Wed Dec 17 | vs Bethune | W112-53 | 10-1 | .909 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 12 | Sun Dec 21 | vs New Hampshire | W93-79 | 11-1 | .917 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 13 | Sun Dec 28 | vs TBD | W114-33 | 12-1 | .923 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 14 | Wed Dec 31 | vs Saint Joseph's | W102-79 | 13-1 | .929 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 15 | Wed Jan 7 | at VCU | W71-62 | 14-1 | .933 | - | CBSSN | Stuart C. Siegel Center · Richmond, VA |
| 16 | Sat Jan 10 | at La Salle | W84-72 | 15-1 | .938 | - | USA Net | Tom Gola Arena · Philadelphia, PA |
| 17 | Wed Jan 14 | vs Fordham | W78-56 | 16-1 | .941 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 18 | Sat Jan 17 | vs Richmond | W88-63 | 17-1 | .944 | - | CBSSN | Chaifetz Arena · St. Louis, MO |
| 19 | Tue Jan 20 | at Duquesne | W81-77 | 18-1 | .947 | #24 | ESPN+ | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 20 | Fri Jan 23 | at St Bonaventure | W97-62 | 19-1 | .950 | #24 | ESPN2 | Reilly Center · Saint Bonaventure, NY |
| 21 | Tue Jan 27 | vs G Washington | W79-76 | 20-1 | .952 | #21 | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 22 | Fri Jan 30 | vs Dayton | W102-71 | 21-1 | .955 | #21 | CBSSN | Chaifetz Arena · St. Louis, MO |
| 23 | Tue Feb 3 | at Davidson | W91-82 | 22-1 | .957 | #19 | CBSSN | John M. Belk Arena · Davidson, NC |
| 24 | Sat Feb 7 | vsLa Salle | W82-58 | 23-1 | .958 | #19 | ESPN+ | Chaifetz Arena · St. Louis, MO |
Loyola Chicago
Rhode Island
George Mason