| 1 | Mon Nov 3 | at Grand Canyon | L71-90 | 0-1 | .000 | - | | GCU Arena · Phoenix, AZ |
| 2 | Fri Nov 7 | at Ohio State | L68-94 | 0-2 | .000 | - | BTN | Value City Arena · Columbus, OH |
| 3 | Sun Nov 9 | vs TBD | W137-56 | 1-2 | .333 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 4 | Wed Nov 12 | at W Michigan | L71-83 | 1-3 | .250 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 5 | Sat Nov 15 | vsTBD | W118-68 | 2-3 | .400 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 6 | Tue Nov 18 | at Utah | L77-85 | 2-4 | .333 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 7 | Fri Nov 21 | at Saint Louis | L60-91 | 2-5 | .286 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 8 | Tue Nov 25 | vs Chicago St | W90-77 | 3-5 | .375 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 9 | Fri Nov 28 | vsTBD | W92-59 | 4-5 | .444 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 10 | Wed Dec 3 | at Oakland | L92-101 | 4-6 | .400 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 11 | Sat Dec 6 | vs N Kentucky | W79-77 | 5-6 | .455 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 12 | Wed Dec 10 | vs E Michigan | W80-65 | 6-6 | .500 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 13 | Sun Dec 14 | vs Detroit Mercy | W81-77 | 7-6 | .538 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 14 | Sun Dec 21 | at Notre Dame | W72-69 | 8-6 | .571 | - | ACC Extra | Purcell Pavilion · South Bend, IN |
| 15 | Mon Dec 29 | at Milwaukee | L55-77 | 8-7 | .533 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 16 | Thu Jan 1 | vs Green Bay | L54-72 | 8-8 | .500 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 17 | Sun Jan 4 | vs Cleveland St | W74-71 | 9-8 | .529 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 18 | Wed Jan 7 | at Youngstown St | W71-69 | 10-8 | .556 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 19 | Sun Jan 11 | at Robert Morris | W79-74 | 11-8 | .579 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 20 | Sun Jan 18 | vsMilwaukee | W100-82 | 12-8 | .600 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 21 | Wed Jan 21 | atDetroit Mercy | W83-76 | 13-8 | .619 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 22 | Sun Jan 25 | at IU Indy | PPD | 14-11 | .560 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 23 | Wed Jan 28 | vsOakland | L65-74 | 13-9 | .591 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 24 | Sat Jan 31 | vsRobert Morris | W83-71 | 14-9 | .609 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 25 | Wed Feb 4 | vsYoungstown St | L61-90 | 14-10 | .583 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 26 | Sat Feb 7 | at Wright St | L68-73 | 14-11 | .560 | - | ESPN+ | Nutter Center · Dayton, OH |
