| 1 | Mon Nov 3 | vs IU Indy | W118-102 | 1-0 | 1.000 | - | B1G+ | Value City Arena · Columbus, OH |
| 2 | Fri Nov 7 | vs Purdue FW | W94-68 | 2-0 | 1.000 | - | BTN | Value City Arena · Columbus, OH |
| 3 | Tue Nov 11 | vs Appalachian St | W75-53 | 3-0 | 1.000 | - | B1G+ | Value City Arena · Columbus, OH |
| 4 | Sun Nov 16 | vs Notre Dame | W64-63 | 4-0 | 1.000 | - | FS1 | Value City Arena · Columbus, OH |
| 5 | Thu Nov 20 | vs W Michigan | W91-58 | 5-0 | 1.000 | - | BTN | Value City Arena · Columbus, OH |
| 6 | Tue Nov 25 | vs Mount St Mary | W113-60 | 6-0 | 1.000 | - | BTN | Value City Arena · Columbus, OH |
| 7 | Fri Nov 28 | at Pitt | L66-67 | 6-1 | .857 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 8 | Sat Dec 6 | at Northwestern | W86-82 | 7-1 | .875 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 9 | Tue Dec 9 | vs #13Illinois | L80-88 | 7-2 | .778 | - | Peacock | Value City Arena · Columbus, OH |
| 10 | Sat Dec 13 | vs West Virginia | W89-88 (2OT) | 8-2 | .800 | - | ESPNU | Value City Arena · Columbus, OH |
| 11 | Sat Dec 20 | vs #12UNC | L70-71 | 8-3 | .727 | - | CBS | State Farm Arena · Atlanta, GA |
| 12 | Tue Dec 23 | vs Grambling | W89-63 | 9-3 | .750 | - | BTN | Value City Arena · Columbus, OH |
| 13 | Fri Jan 2 | at Rutgers | W80-73 | 10-3 | .769 | - | Peacock | Jersey Mike’s Arena · Piscataway, NJ |
| 14 | Mon Jan 5 | vs #10Nebraska | L69-72 | 10-4 | .714 | - | FS1 | Value City Arena · Columbus, OH |
| 15 | Thu Jan 8 | at Oregon | W72-62 | 11-4 | .733 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 16 | Sun Jan 11 | at Washington | L74-81 | 11-5 | .688 | - | Peacock | Alaska Airlines Arena · Seattle, WA |
| 17 | Sat Jan 17 | vs UCLA | W86-74 | 12-5 | .706 | - | CBS | Value City Arena · Columbus, OH |
| 18 | Tue Jan 20 | vs Minnesota | W82-74 (OT) | 13-5 | .722 | - | BTN | Value City Arena · Columbus, OH |
| 19 | Fri Jan 23 | at #3Michigan | L62-74 | 13-6 | .684 | - | FOX | Crisler Center · Ann Arbor, MI |
| 20 | Mon Jan 26 | vs Penn State | W84-78 | 14-6 | .700 | - | FS1 | Value City Arena · Columbus, OH |
| 21 | Sat Jan 31 | at Wisconsin | L82-92 | 14-7 | .667 | - | FOX | Kohl Center · Madison, WI |
| 22 | Thu Feb 5 | at Maryland | W82-62 | 15-7 | .682 | - | FS1 | XFINITY Center · College Park, MD |
| 23 | Sun Feb 8 | vs#2Michigan | L61-82 | 15-8 | .652 | - | CBS | Value City Arena · Columbus, OH |
USC
#15Virginia
#10Michigan St
Iowa
#13Purdue
Indiana