| 1 | Mon Nov 3 | vs Rider | W87-53 | 1-0 | 1.000 | - | ACC Extra | John Paul Jones Arena · Charlottesville, VA |
| 2 | Fri Nov 7 | vs NC Central | W81-62 | 2-0 | 1.000 | - | ACC Extra | John Paul Jones Arena · Charlottesville, VA |
| 3 | Tue Nov 11 | vs Hampton | W91-53 | 3-0 | 1.000 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 4 | Sat Nov 15 | vs Marshall | W104-78 | 4-0 | 1.000 | - | ACC Extra | John Paul Jones Arena · Charlottesville, VA |
| 5 | Fri Nov 21 | vs Northwestern | W83-78 | 5-0 | 1.000 | - | CBSSN | John Paul Jones Arena · Charlottesville, VA |
| 6 | Sun Nov 23 | vs Butler | L73-80 | 5-1 | .833 | - | CBSSN | John Paul Jones Arena · Charlottesville, VA |
| 7 | Fri Nov 28 | vs Queens | W94-69 | 6-1 | .857 | - | ACC Extra | John Paul Jones Arena · Charlottesville, VA |
| 8 | Wed Dec 3 | at Texas | W88-69 | 7-1 | .875 | - | ESPNU | Moody Center · Austin, TX |
| 9 | Sat Dec 6 | vs Dayton | W86-73 | 8-1 | .889 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 10 | Tue Dec 9 | vs MD-Eastern | W84-60 | 9-1 | .900 | #24 | ACC Extra | John Paul Jones Arena · Charlottesville, VA |
| 11 | Sat Dec 20 | vs Maryland | W80-72 | 10-1 | .909 | #23 | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 12 | Mon Dec 22 | vs American | W95-51 | 11-1 | .917 | #21 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 13 | Wed Dec 31 | at Virginia Tech | L85-95 (3OT) | 11-2 | .846 | #21 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 14 | Sat Jan 3 | at NC State | W76-61 | 12-2 | .857 | #21 | ESPN2 | PNC Arena · Raleigh, NC |
| 15 | Wed Jan 7 | vs California | W84-60 | 13-2 | .867 | #23 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 16 | Sat Jan 10 | vs Stanford | W70-55 | 14-2 | .875 | #23 | The CW Network | John Paul Jones Arena · Charlottesville, VA |
| 17 | Tue Jan 13 | at #20Louisville | W79-70 | 15-2 | .882 | #16 | ESPN2 | KFC Yum! Center · Louisville, KY |
| 18 | Sat Jan 17 | at SMU | W72-68 | 16-2 | .889 | #16 | ESPN2 | Moody Coliseum · Dallas, TX |
| 19 | Sat Jan 24 | vs #22UNC | L80-85 | 16-3 | .842 | #14 | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 20 | Tue Jan 27 | at Notre Dame | W100-97 (2OT) | 17-3 | .850 | #17 | ESPN2 | Purcell Pavilion · South Bend, IN |
| 21 | Sat Jan 31 | at Boston College | W73-66 | 18-3 | .857 | #17 | The CW Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 22 | Tue Feb 3 | vs Pitt | W67-47 | 19-3 | .864 | #18 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 23 | Sat Feb 7 | vs Syracuse | W72-59 | 20-3 | .870 | #18 | ESPN | John Paul Jones Arena · Charlottesville, VA |
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