| 1 | Mon Nov 3 | vs Youngstown St | W74-59 | 1-0 | 1.000 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 2 | Fri Nov 7 | vs Longwood | W78-60 | 2-0 | 1.000 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 3 | Mon Nov 10 | vs E Michigan | W78-66 | 3-0 | 1.000 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 4 | Thu Nov 13 | at West Virginia | L49-71 | 3-1 | .750 | - | FS1 | WVU Coliseum · Morgantown, WV |
| 5 | Mon Nov 17 | vs Bucknell | W84-50 | 4-1 | .800 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 6 | Thu Nov 20 | at UCF | L67-77 | 4-2 | .667 | - | ESPN2 | Addition Financial Arena · Orlando, FL |
| 7 | Sun Nov 23 | vs Quinnipiac | L75-83 | 4-3 | .571 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 8 | Fri Nov 28 | vs Ohio State | W67-66 | 5-3 | .625 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 9 | Tue Dec 2 | vs Texas A&M | L73-81 | 5-4 | .556 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 10 | Sun Dec 7 | vs Hofstra | L73-80 | 5-5 | .500 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 11 | Sat Dec 13 | at Villanova | L61-79 | 5-6 | .455 | - | truTV | Finneran Pavilion · Villanova, PA |
| 12 | Wed Dec 17 | vs Binghamton | W103-63 | 6-6 | .500 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 13 | Sun Dec 21 | at Penn State | W80-46 | 7-6 | .538 | - | BTN | Bryce Jordan Center · University Park, PA |
| 14 | Tue Dec 30 | at Miami | L69-76 | 7-7 | .500 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 15 | Sat Jan 3 | vs Clemson | L68-73 | 7-8 | .467 | - | The CW Network | Petersen Events Center · Pittsburgh, PA |
| 16 | Sat Jan 10 | vs Syracuse | L72-83 | 7-9 | .438 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 17 | Wed Jan 14 | at Georgia Tech | W89-66 | 8-9 | .471 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 18 | Sat Jan 17 | vs #20Louisville | L59-100 | 8-10 | .444 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 19 | Wed Jan 21 | at Boston College | L62-65 | 8-11 | .421 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 20 | Sat Jan 24 | vs NC State | L72-81 | 8-12 | .400 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 21 | Tue Jan 27 | vs Wake Forest | W80-76 (OT) | 9-12 | .429 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 22 | Sat Jan 31 | at#22Clemson | L52-63 | 9-13 | .409 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 23 | Tue Feb 3 | at #18Virginia | L47-67 | 9-14 | .391 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 24 | Sat Feb 7 | vs SMU | L67-86 | 9-15 | .375 | - | The CW Network | Petersen Events Center · Pittsburgh, PA |
#4Duke
#11UNC
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