| 1 | Mon Nov 3 | vs Georgia St | W71-49 | 1-0 | 1.000 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 2 | Mon Nov 10 | at Pitt | L66-78 | 1-1 | .500 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 3 | Fri Nov 14 | vs IU Indy | L83-90 | 1-2 | .333 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 4 | Tue Nov 18 | at Detroit Mercy | W72-62 | 2-2 | .500 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 5 | Fri Nov 21 | vs Oakland | W97-91 | 3-2 | .600 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 6 | Mon Nov 24 | at #6Louisville | L46-87 | 3-3 | .500 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 7 | Wed Nov 26 | at Cincinnati | W64-56 | 4-3 | .571 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 8 | Fri Nov 28 | vs NJIT | W73-55 | 5-3 | .625 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 9 | Tue Dec 2 | at Butler | L68-84 | 5-4 | .556 | - | truTV | Hinkle Fieldhouse · Indianapolis, IN |
| 10 | Fri Dec 5 | vs TBD | W86-48 | 6-4 | .600 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 11 | Wed Dec 10 | at Purdue FW | L65-80 | 6-5 | .545 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 12 | Fri Dec 19 | at Akron | L72-93 | 6-6 | .500 | - | ESPN+ | James A. Rhodes Arena · Akron, OH |
| 13 | Mon Dec 22 | at Wright St | L64-70 | 6-7 | .462 | - | ESPN+ | Nutter Center · Dayton, OH |
| 14 | Tue Dec 30 | vs UMass | W80-74 | 7-7 | .500 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 15 | Sat Jan 3 | vs Ohio | L67-68 | 7-8 | .467 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 16 | Tue Jan 6 | at Ball State | W74-52 | 8-8 | .500 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 17 | Sat Jan 10 | at W Michigan | L62-79 | 8-9 | .471 | - | ESPN+ | University Arena (MI) · Kalamazoo, MI |
| 18 | Tue Jan 13 | vs N Illinois | W77-59 | 9-9 | .500 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 19 | Sat Jan 17 | at Bowling Green | L79-85 | 9-10 | .474 | - | ESPN+ | Stroh Center · Bowling Green, OH |
| 20 | Sat Jan 24 | vs Kent State | L75-76 (2OT) | 9-11 | .450 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 21 | Tue Jan 27 | at C Michigan | L65-100 | 9-12 | .429 | - | ESPN+ | McGuirk Arena · Mount Pleasant, MI |
| 22 | Sat Jan 31 | atUMass | L67-70 | 9-13 | .409 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 23 | Tue Feb 3 | vsAkron | L64-66 | 9-14 | .391 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 24 | Sat Feb 7 | at Appalachian St | L60-65 | 9-15 | .375 | - | ESPN+ | Holmes Convocation Center · Boone, NC |
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