| 1 | Mon Nov 3 | at UIC | L71-91 | 0-1 | .000 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 2 | Fri Nov 7 | at Notre Dame | L70-102 | 0-2 | .000 | - | ACC Extra | Purcell Pavilion · South Bend, IN |
| 3 | Tue Nov 11 | vs TBD | W92-54 | 1-2 | .333 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 4 | Sat Nov 15 | at Toledo | L83-90 | 1-3 | .250 | - | ESPN+ | Savage Arena · Toledo, OH |
| 5 | Tue Nov 18 | vs E Michigan | L62-72 | 1-4 | .200 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 6 | Fri Nov 21 | at #17Michigan St | L56-84 | 1-5 | .167 | - | BTN | Breslin Center · East Lansing, MI |
| 7 | Sun Nov 23 | at DePaul | L75-95 | 1-6 | .143 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 8 | Sat Nov 29 | at Niagara | W70-66 | 2-6 | .250 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 9 | Wed Dec 3 | vs IU Indy | W92-78 | 3-6 | .333 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 10 | Sat Dec 6 | at Cleveland St | W71-59 | 4-6 | .400 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 11 | Sun Dec 14 | at Purdue FW | L77-81 | 4-7 | .364 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 12 | Sat Dec 20 | vsTBD | W91-60 | 5-7 | .417 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 13 | Mon Dec 29 | at Youngstown St | W73-68 | 6-7 | .462 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 14 | Fri Jan 2 | vs Robert Morris | L77-85 | 6-8 | .429 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 15 | Fri Jan 9 | vs Wright St | L82-84 | 6-9 | .400 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 16 | Sun Jan 11 | vsCleveland St | W94-84 | 7-9 | .438 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 17 | Thu Jan 15 | at N Kentucky | L71-96 | 7-10 | .412 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 18 | Sat Jan 17 | atIU Indy | W80-77 | 8-10 | .444 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 19 | Wed Jan 21 | vsPurdue FW | L76-83 | 8-11 | .421 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 20 | Sat Jan 24 | vs Oakland | L87-95 | 8-12 | .400 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 21 | Fri Jan 30 | vsN Kentucky | W90-77 | 9-12 | .429 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 22 | Wed Feb 4 | at Milwaukee | W76-63 | 10-12 | .455 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 23 | Sat Feb 7 | at Green Bay | L63-76 | 10-13 | .435 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
