| 1 | Mon Nov 3 | vs Hampton | W90-86 | 1-0 | 1.000 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 2 | Sat Nov 8 | at Wofford | L76-86 | 1-1 | .500 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 3 | Mon Nov 10 | vs Little Rock | W92-72 | 2-1 | .667 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 4 | Wed Nov 12 | at Indiana | L70-101 | 2-2 | .500 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 5 | Fri Nov 14 | at #11Texas Tech | L63-80 | 2-3 | .400 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 6 | Sat Nov 22 | at Wichita St | L58-75 | 2-4 | .333 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 7 | Tue Nov 25 | vs TBD | W125-70 | 3-4 | .429 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 8 | Sat Nov 29 | at Akron | L81-105 | 3-5 | .375 | - | ESPN+ | James A. Rhodes Arena · Akron, OH |
| 9 | Sat Dec 6 | vs Robert Morris | W74-72 | 4-5 | .444 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 10 | Sun Dec 14 | vs Indiana St | L68-70 | 4-6 | .400 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 11 | Fri Dec 19 | vs S Dakota St | W88-87 | 5-6 | .455 | - | | Fiserv Forum · Milwaukee, WI |
| 12 | Sun Dec 21 | at Cleveland St | W81-71 | 6-6 | .500 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 13 | Mon Dec 29 | vs Purdue FW | W77-55 | 7-6 | .538 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 14 | Tue Dec 30 | at Wisconsin | L60-80 | 7-7 | .500 | - | BTN | Kohl Center · Madison, WI |
| 15 | Thu Jan 1 | at Wright St | L70-76 | 7-8 | .467 | - | ESPN+ | Nutter Center · Dayton, OH |
| 16 | Mon Jan 5 | at Green Bay | L76-79 | 7-9 | .438 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 17 | Fri Jan 9 | vs N Kentucky | L67-85 | 7-10 | .412 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 18 | Sun Jan 11 | vs IU Indy | W95-83 | 8-10 | .444 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 19 | Thu Jan 15 | vs Oakland | L60-73 | 8-11 | .421 | - | ESPNU | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 20 | Sun Jan 18 | atPurdue FW | L82-100 | 8-12 | .400 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 21 | Thu Jan 22 | atRobert Morris | L76-88 | 8-13 | .381 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 22 | Sat Jan 24 | at Youngstown St | W65-64 | 9-13 | .409 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 23 | Fri Jan 30 | vsWright St | L69-76 | 9-14 | .391 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 24 | Sun Feb 1 | vsCleveland St | L88-90 | 9-15 | .375 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 25 | Wed Feb 4 | vs Detroit Mercy | L63-76 | 9-16 | .360 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 26 | Sat Feb 7 | atN Kentucky | L62-67 | 9-17 | .346 | - | ESPN+ | Truist Arena · Highland Heights, KY |
