| 1 | Mon Nov 3 | at George Mason | L46-70 | 0-1 | .000 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 2 | Sat Nov 8 | vs Milwaukee | W86-76 | 1-1 | .500 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 3 | Tue Nov 11 | at #22Auburn | L62-93 | 1-2 | .333 | - | SECN+ | Neville Arena · Auburn, AL |
| 4 | Sat Nov 15 | at Bellarmine | W94-86 | 2-2 | .500 | - | ESPN+ | Knights Hall · Louisville, KY |
| 5 | Wed Nov 19 | vs North Florida | W86-78 | 3-2 | .600 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 6 | Fri Nov 21 | vs TBD | W81-57 | 4-2 | .667 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 7 | Wed Nov 26 | at N Kentucky | L83-93 | 4-3 | .571 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 8 | Sat Nov 29 | at E Kentucky | W83-77 | 5-3 | .625 | - | ESPN+ | McBrayer Arena · Richmond, KY |
| 9 | Wed Dec 3 | vs Presbyterian | W63-56 | 6-3 | .667 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 10 | Sat Dec 6 | vs Elon | L52-73 | 6-4 | .600 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 11 | Mon Dec 15 | at Gardner-Webb | W83-57 | 7-4 | .636 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 12 | Wed Dec 17 | at Wichita St | L73-84 | 7-5 | .583 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 13 | Sun Dec 28 | vsTBD | W88-54 | 8-5 | .615 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 14 | Wed Dec 31 | at W Carolina | W79-74 | 9-5 | .643 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 15 | Sat Jan 3 | at The Citadel | W95-86 | 10-5 | .667 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 16 | Wed Jan 7 | vs UNC Greensboro | W97-85 | 11-5 | .688 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 17 | Sat Jan 10 | at Mercer | L97-109 | 11-6 | .647 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 18 | Wed Jan 14 | vs Chattanooga | L67-76 | 11-7 | .611 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 19 | Sat Jan 17 | at Furman | W74-70 | 12-7 | .632 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 20 | Wed Jan 21 | vs Samford | W88-78 | 13-7 | .650 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 21 | Sat Jan 24 | vsMercer | W80-77 | 14-7 | .667 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 22 | Thu Jan 29 | atChattanooga | W81-55 | 15-7 | .682 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 23 | Sun Feb 1 | vs ETSU | L72-86 | 15-8 | .652 | - | CBSSN | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 24 | Wed Feb 4 | at VMI | W81-67 | 16-8 | .667 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 25 | Sat Feb 7 | vsW Carolina | W77-66 | 17-8 | .680 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
