| 1 | Mon Nov 3 | at Minnesota | L60-87 | 0-1 | .000 | - | B1G+ | Williams Arena · Minneapolis, MN |
| 2 | Fri Nov 7 | at Clemson | L59-97 | 0-2 | .000 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 3 | Mon Nov 10 | vs TBD | L81-92 | 0-3 | .000 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 4 | Sat Nov 15 | at Elon | L84-95 | 0-4 | .000 | - | | Schar Center · Elon, NC |
| 5 | Tue Nov 18 | at DePaul | L62-93 | 0-5 | .000 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 6 | Sat Nov 22 | at Richmond | L67-102 | 0-6 | .000 | - | ESPN+ | Robins Center · Richmond, VA |
| 7 | Wed Nov 26 | vs Navy | L51-84 | 0-7 | .000 | - | | Trask Coliseum · Wilmington, NC |
| 8 | Fri Nov 28 | vs SE Louisiana | L68-76 | 0-8 | .000 | - | | Trask Coliseum · Wilmington, NC |
| 9 | Sat Nov 29 | at UNC Wilmington | L62-88 | 0-9 | .000 | - | | Trask Coliseum · Wilmington, NC |
| 10 | Wed Dec 3 | at Queens | L74-107 | 0-10 | .000 | - | ESPN+ | Curry Arena · Charlotte, NC |
| 11 | Sat Dec 6 | vs Georgia So | L84-88 | 0-11 | .000 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 12 | Fri Dec 12 | vsTBD | W77-63 | 1-11 | .083 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 13 | Mon Dec 15 | vs Wofford | L57-83 | 1-12 | .077 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 14 | Thu Dec 18 | vsTBD | W105-65 | 2-12 | .143 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 15 | Sun Dec 21 | at #20Tennessee | L52-94 | 2-13 | .133 | - | SECN+ | Thompson-Boling Arena · Knoxville, TN |
| 16 | Wed Dec 31 | vs Charleston So | L79-89 | 2-14 | .125 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 17 | Sat Jan 3 | at Winthrop | L77-88 | 2-15 | .118 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 18 | Wed Jan 7 | at High Point | L49-104 | 2-16 | .111 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 19 | Wed Jan 14 | vs Radford | L80-89 | 2-17 | .105 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 20 | Sat Jan 17 | vs Presbyterian | L55-92 | 2-18 | .100 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 21 | Wed Jan 21 | at Longwood | L56-91 | 2-19 | .095 | - | ESPN+ | Willett Hall · Farmville, VA |
| 22 | Fri Jan 23 | vs SC Upstate | W67-65 | 3-19 | .136 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 23 | Thu Jan 29 | at UNC Asheville | L50-69 | 3-20 | .130 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 24 | Wed Feb 4 | vsLongwood | L66-86 | 3-21 | .125 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 25 | Sat Feb 7 | atPresbyterian | L62-68 | 3-22 | .120 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
