| 1 | Mon Nov 3 | vs Mercer | W76-61 | 1-0 | 1.000 | #18 | SECN+ | Thompson-Boling Arena · Knoxville, TN |
| 2 | Sat Nov 8 | vs N Kentucky | W95-56 | 2-0 | 1.000 | #18 | SECN+ | Thompson-Boling Arena · Knoxville, TN |
| 3 | Wed Nov 12 | vs North Florida | W99-66 | 3-0 | 1.000 | #20 | SECN+ | Thompson-Boling Arena · Knoxville, TN |
| 4 | Mon Nov 17 | vs Rice | W91-66 | 4-0 | 1.000 | #20 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 5 | Thu Nov 20 | vs Tennessee St | W89-60 | 5-0 | 1.000 | #20 | SECN+ | Thompson-Boling Arena · Knoxville, TN |
| 6 | Mon Nov 24 | vs Rutgers | W85-60 | 6-0 | 1.000 | #17 | TNT | Thompson-Boling Arena · Knoxville, TN |
| 7 | Tue Nov 25 | at #3Houston | W76-73 | 7-0 | 1.000 | #17 | TNT | Fertitta Center · Houston, TX |
| 8 | Wed Nov 26 | vs Kansas | L76-81 | 7-1 | .875 | #17 | TNT | Thompson-Boling Arena · Knoxville, TN |
| 9 | Tue Dec 2 | at Syracuse | L60-62 | 7-2 | .778 | #13 | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 10 | Sat Dec 6 | vs #14Illinois | L62-75 | 7-3 | .700 | #13 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 11 | Tue Dec 16 | vs #11Louisville | W83-62 | 8-3 | .727 | #20 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 12 | Sun Dec 21 | vs Gardner-Webb | W94-52 | 9-3 | .750 | #20 | SECN+ | Thompson-Boling Arena · Knoxville, TN |
| 13 | Tue Dec 30 | vs SC State | W105-54 | 10-3 | .769 | #19 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 14 | Sat Jan 3 | at #18Arkansas | L75-86 | 10-4 | .714 | #19 | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 15 | Tue Jan 6 | vs Texas | W85-71 | 11-4 | .733 | #21 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 16 | Sat Jan 10 | at Florida | L67-91 | 11-5 | .688 | #21 | ESPN | O'Connell Center · Gainesville, FL |
| 17 | Tue Jan 13 | vs Texas A&M | W87-82 (2OT) | 12-5 | .706 | #24 | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 18 | Sat Jan 17 | vs Kentucky | L78-80 | 12-6 | .667 | #24 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 19 | Sat Jan 24 | at #17Alabama | W79-73 | 13-6 | .684 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 20 | Wed Jan 28 | at Georgia | W86-85 (OT) | 14-6 | .700 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 21 | Sat Jan 31 | vs Auburn | W77-69 | 15-6 | .714 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 22 | Tue Feb 3 | vs Ole Miss | W84-66 | 16-6 | .727 | #25 | ESPN2 | Thompson-Boling Arena · Knoxville, TN |
| 23 | Sat Feb 7 | atKentucky | L71-74 | 16-7 | .696 | #25 | ESPN | Rupp Arena · Lexington, KY |
Mississippi St
LSU
Oklahoma
#19Vanderbilt
Missouri
South Carolina