| 1 | Mon Nov 3 | at #11Louisville | L45-104 | 0-1 | .000 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 2 | Fri Nov 7 | at Samford | L72-82 | 0-2 | .000 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 3 | Mon Nov 10 | at NC A&T | L62-85 | 0-3 | .000 | - | | Corbett Sports Center · Greensboro, NC |
| 4 | Fri Nov 14 | at Charleston | L61-88 | 0-4 | .000 | - | | TD Arena · Charleston, SC |
| 5 | Wed Nov 19 | vs Chattanooga | L66-78 | 0-5 | .000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 6 | Sun Nov 23 | at South Dakota | L81-82 | 0-6 | .000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 7 | Tue Nov 25 | at Missouri | L66-98 | 0-7 | .000 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 8 | Sat Nov 29 | at Winthrop | L79-101 | 0-8 | .000 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 9 | Fri Dec 5 | at Bethune | L59-80 | 0-9 | .000 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 10 | Mon Dec 8 | at Charleston So | L44-84 | 0-10 | .000 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 11 | Fri Dec 12 | at Queens | L78-102 | 0-11 | .000 | - | ESPN+ | Curry Arena · Charlotte, NC |
| 12 | Tue Dec 16 | vs SC Upstate | L72-78 | 0-12 | .000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 13 | Fri Dec 19 | vs TBD | W68-54 | 1-12 | .077 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 14 | Mon Dec 22 | at South Carolina | L70-95 | 1-13 | .071 | - | SECN+ | Colonial Life Arena · Columbia, SC |
| 15 | Tue Dec 30 | at #19Tennessee | L54-105 | 1-14 | .067 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 16 | Sat Jan 3 | vs Howard | W58-57 | 2-14 | .125 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 17 | Sat Jan 10 | at Morgan St | L67-72 | 2-15 | .118 | - | ESPN+ | Hill Field House · Baltimore, MD |
| 18 | Mon Jan 12 | at Coppin St | W74-72 | 3-15 | .167 | - | ESPN+ | Physical Education Complex · Baltimore, MD |
| 19 | Sat Jan 17 | vs Norfolk St | L82-89 | 3-16 | .158 | - | ESPN+ | S-H-M Memorial Center · Orangeburg, SC |
| 20 | Tue Jan 20 | vs TBD | W56-50 | 4-16 | .200 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 21 | Mon Jan 26 | vs Delaware St | W70-64 | 5-16 | .238 | - | ESPN+ | S-H-M Memorial Center · Orangeburg, SC |
| 22 | Sat Jan 31 | vs NC Central | PPD | 6-17 | .261 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 23 | Wed Feb 4 | vs MD-Eastern | W63-54 | 6-16 | .273 | - | ESPN+ | S-H-M Memorial Center · Orangeburg, SC |
| 24 | Sat Feb 7 | at Howard | L57-85 | 6-17 | .261 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |