| 1 | Mon Nov 3 | vs TBD | W79-58 | 1-0 | 1.000 | - | | TD Arena · Charleston, SC |
| 2 | Fri Nov 7 | at Liberty | L75-90 | 1-1 | .500 | - | YouTube | Liberty Arena · Lynchburg, VA |
| 3 | Sat Nov 8 | vs FAU | L77-94 | 1-2 | .333 | - | | Liberty Arena · Lynchburg, VA |
| 4 | Fri Nov 14 | vs SC State | W88-61 | 2-2 | .500 | - | | TD Arena · Charleston, SC |
| 5 | Mon Nov 17 | vs Drake | L62-71 | 2-3 | .400 | - | | TD Arena · Charleston, SC |
| 6 | Fri Nov 21 | vs UMass | W69-65 | 3-3 | .500 | - | ESPN+ | TD Arena · Charleston, SC |
| 7 | Sun Nov 23 | vs Yale | L63-74 | 3-4 | .429 | - | ESPN+ | TD Arena · Charleston, SC |
| 8 | Mon Nov 24 | at Evansville | W78-59 | 4-4 | .500 | - | | Ford Center · Evansville, IN |
| 9 | Sun Nov 30 | vs Belmont | L73-96 | 4-5 | .444 | - | | TD Arena · Charleston, SC |
| 10 | Wed Dec 10 | at South Florida | L75-81 | 4-6 | .400 | - | ESPN+ | Yuengling Center · Tampa, FL |
| 11 | Sun Dec 14 | vs Charlotte | W74-67 | 5-6 | .455 | - | | TD Arena · Charleston, SC |
| 12 | Wed Dec 17 | vs The Citadel | W82-78 | 6-6 | .500 | - | | TD Arena · Charleston, SC |
| 13 | Sun Dec 21 | at N Kentucky | W85-74 | 7-6 | .538 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 14 | Mon Dec 29 | vs Drexel | W72-63 | 8-6 | .571 | - | The CW Network | TD Arena · Charleston, SC |
| 15 | Wed Dec 31 | at Elon | W85-81 | 9-6 | .600 | - | | Schar Center · Elon, NC |
| 16 | Mon Jan 5 | vs William & Mary | W88-79 | 10-6 | .625 | - | CBSSN | TD Arena · Charleston, SC |
| 17 | Sat Jan 10 | vs Hampton | W74-70 | 11-6 | .647 | - | | TD Arena · Charleston, SC |
| 18 | Thu Jan 15 | at Towson | L52-61 | 11-7 | .611 | - | CBSSN | SECU Arena · Towson, MD |
| 19 | Sat Jan 17 | at Stony Brook | L106-112 (2OT) | 11-8 | .579 | - | | Island FCU Arena · Stony Brook, NY |
| 20 | Thu Jan 22 | vs Campbell | W87-83 | 12-8 | .600 | - | The CW Network | TD Arena · Charleston, SC |
| 21 | Sat Jan 24 | vsElon | W80-70 | 13-8 | .619 | - | | TD Arena · Charleston, SC |
| 22 | Thu Jan 29 | at Hofstra | W66-64 | 14-8 | .636 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 23 | Sat Jan 31 | at Northeastern | W89-84 | 15-8 | .652 | - | | Matthews Arena · Boston, MA |
| 24 | Thu Feb 5 | vs NC A&T | W78-62 | 16-8 | .667 | - | | TD Arena · Charleston, SC |
| 25 | Mon Feb 9 | vs UNC Wilmington | L64-76 | 16-9 | .640 | - | CBSSN | TD Arena · Charleston, SC |
Monmouth