| 1 | Fri Nov 7 | at Navy | W97-68 | 1-0 | 1.000 | - | CBSSN | Alumni Hall (Navy) · Annapolis, MD |
| 2 | Tue Nov 11 | at Quinnipiac | W97-60 | 2-0 | 1.000 | - | ESPN+ | M&T Bank Arena · Hamden, CT |
| 3 | Sat Nov 15 | vs Stony Brook | W86-79 | 3-0 | 1.000 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 4 | Tue Nov 18 | vs Rhode Island | L77-86 | 3-1 | .750 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 5 | Fri Nov 21 | vs Green Bay | W73-67 | 4-1 | .800 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 6 | Sun Nov 23 | at Charleston | W74-63 | 5-1 | .833 | - | ESPN+ | TD Arena · Charleston, SC |
| 7 | Mon Nov 24 | at Akron | W97-94 | 6-1 | .857 | - | | James A. Rhodes Arena · Akron, OH |
| 8 | Sun Nov 30 | at Vermont | W77-74 | 7-1 | .875 | - | ESPN+ | Patrick Gymnasium · Burlington, VT |
| 9 | Tue Dec 2 | vs TBD | W117-53 | 8-1 | .889 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 10 | Wed Dec 3 | vsTBD | W79-61 | 9-1 | .900 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 11 | Sun Dec 7 | vs UIC | W80-66 | 10-1 | .909 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 12 | Wed Dec 10 | vs Albany | W93-82 | 11-1 | .917 | - | ESPNU | John J. Lee Amphitheater · New Haven, CT |
| 13 | Mon Dec 29 | at #14Alabama | L78-102 | 11-2 | .846 | - | SECN+ | Coleman Coliseum · Tuscaloosa, AL |
| 14 | Mon Jan 5 | at Brown | W70-53 | 12-2 | .857 | - | ESPN+ | Pizzitola Sports Center · Providence, RI |
| 15 | Sat Jan 10 | at Princeton | L60-76 | 12-3 | .800 | - | ESPN+ | Jadwin Gymnasium · Princeton, NJ |
| 16 | Sat Jan 17 | vs Cornell | W102-68 | 13-3 | .813 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 17 | Mon Jan 19 | vs Columbia | W91-74 | 14-3 | .824 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 18 | Sat Jan 24 | at Penn | W77-60 | 15-3 | .833 | - | ESPNU | The Palestra · Philadelphia, PA |
| 19 | Fri Jan 30 | vs Dartmouth | W83-68 | 16-3 | .842 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 20 | Sat Jan 31 | vs Harvard | L65-67 | 16-4 | .800 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 21 | Fri Feb 6 | vsBrown | W81-69 | 17-4 | .810 | - | ESPN+ | John J. Lee Amphitheater · New Haven, CT |
| 22 | Mon Feb 9 | at Howard | W87-81 (OT) | 18-4 | .818 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
