| 1 | Fri Nov 7 | vs TBD | W119-72 | 1-0 | 1.000 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 2 | Sun Nov 9 | at American | L78-84 | 1-1 | .500 | - | ESPN+ | Bender Arena · Washington, D.C. |
| 3 | Tue Nov 11 | at Providence | L81-106 | 1-2 | .333 | - | ESPN+ | Amica Mutual Pavilion · Providence, RI |
| 4 | Mon Nov 17 | vs Saint Joseph's | W83-74 | 2-2 | .500 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 5 | Fri Nov 21 | at Drexel | W84-68 | 3-2 | .600 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 6 | Fri Nov 28 | vs Merrimack | W77-65 | 4-2 | .667 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 7 | Sat Nov 29 | vs La Salle | W73-71 | 5-2 | .714 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 8 | Sun Nov 30 | vs Hofstra | L60-77 | 5-3 | .625 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 9 | Sat Dec 6 | at Villanova | L63-90 | 5-4 | .556 | - | | Finneran Pavilion · Villanova, PA |
| 10 | Mon Dec 8 | vs Lafayette | W74-72 | 6-4 | .600 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 11 | Sat Dec 20 | at Rutgers | L69-70 | 6-5 | .545 | - | BTN | Jersey Mike’s Arena · Piscataway, NJ |
| 12 | Sun Dec 28 | at George Mason | L79-83 | 6-6 | .500 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 13 | Wed Dec 31 | vs NJIT | W80-61 | 7-6 | .538 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 14 | Mon Jan 5 | at Princeton | L76-78 | 7-7 | .500 | - | ESPN+ | Jadwin Gymnasium · Princeton, NJ |
| 15 | Sat Jan 10 | vs Brown | W81-73 | 8-7 | .533 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 16 | Sat Jan 17 | at Dartmouth | W84-74 | 9-7 | .563 | - | ESPN+ | Edward Leede Arena · Hanover, NH |
| 17 | Mon Jan 19 | at Harvard | L63-64 | 9-8 | .529 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 18 | Sat Jan 24 | vs Yale | L60-77 | 9-9 | .500 | - | ESPNU | The Palestra · Philadelphia, PA |
| 19 | Fri Jan 30 | at Columbia | L67-72 | 9-10 | .474 | - | ESPN+ | Francis S. Levien Gymnasium · New York, NY |
| 20 | Sat Jan 31 | at Cornell | W91-81 | 10-10 | .500 | - | ESPN+ | Newman Arena · Ithaca, NY |
| 21 | Sat Feb 7 | vsPrinceton | W61-60 | 11-10 | .524 | - | ESPNU | The Palestra · Philadelphia, PA |
