| 1 | Mon Nov 3 | at Saint Joseph's | L76-85 | 0-1 | .000 | - | ESPN+ | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 2 | Wed Nov 5 | vs TBD | W79-44 | 1-1 | .500 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 3 | Sat Nov 8 | at Texas | L60-97 | 1-2 | .333 | - | SECN+ | Moody Center · Austin, TX |
| 4 | Thu Nov 13 | vs Cornell | L78-97 | 1-3 | .250 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 5 | Mon Nov 17 | at West Virginia | L59-81 | 1-4 | .200 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 6 | Fri Nov 21 | at Stonehill | L70-74 | 1-5 | .167 | - | | placeholder · sf, ca |
| 7 | Fri Nov 28 | vs Le Moyne | L63-76 | 1-6 | .143 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 8 | Sat Nov 29 | vs Ball State | W55-37 | 2-6 | .250 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 9 | Sun Nov 30 | vs Monmouth | L74-88 | 2-7 | .222 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 10 | Fri Dec 5 | vs Mercyhurst | W79-71 | 3-7 | .300 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 11 | Mon Dec 8 | at Penn | L72-74 | 3-8 | .273 | - | ESPN+ | The Palestra · Philadelphia, PA |
| 12 | Thu Dec 18 | at Charlotte | L67-81 | 3-9 | .250 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 13 | Sat Dec 20 | at Georgia Tech | L81-95 | 3-10 | .231 | - | ACC Extra | McCamish Pavilion · Atlanta, GA |
| 14 | Wed Dec 31 | vs Colgate | L77-85 | 3-11 | .214 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 15 | Sat Jan 3 | at Loyola MD | W79-64 | 4-11 | .267 | - | ESPN+ | Reitz Arena · Baltimore, MD |
| 16 | Wed Jan 7 | vs Boston Univ | L67-83 | 4-12 | .250 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 17 | Sat Jan 10 | at Navy | L50-76 | 4-13 | .235 | - | ESPN+ | Alumni Hall (Navy) · Annapolis, MD |
| 18 | Wed Jan 14 | at Bucknell | L69-76 | 4-14 | .222 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 19 | Sat Jan 17 | vs Holy Cross | W74-55 | 5-14 | .263 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 20 | Wed Jan 21 | atBoston Univ | L73-77 (OT) | 5-15 | .250 | - | ESPN+ | Case Gym · Boston, MA |
| 21 | Sat Jan 24 | at Lehigh | L59-64 | 5-16 | .238 | - | ESPN+ | Stabler Arena · Bethlehem, PA |
| 22 | Wed Jan 28 | vsBucknell | W81-79 | 6-16 | .273 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 23 | Sat Jan 31 | at American | W67-65 | 7-16 | .304 | - | | Bender Arena · Washington, D.C. |
| 24 | Wed Feb 4 | vsNavy | L50-65 | 7-17 | .292 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 25 | Sat Feb 7 | at Army | W63-60 | 8-17 | .320 | - | ESPN+ | Christl Arena · West Point, NY |
