| 1 | Mon Nov 3 | vs Delaware | W78-70 | 1-0 | 1.000 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 2 | Fri Nov 7 | at Mount St Mary | W73-62 | 2-0 | 1.000 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 3 | Tue Nov 11 | at Princeton | L63-73 | 2-1 | .667 | - | ESPN+ | Jadwin Gymnasium · Princeton, NJ |
| 4 | Fri Nov 14 | vs Hofstra | L77-83 | 2-2 | .500 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 5 | Mon Nov 17 | at Pitt | L50-84 | 2-3 | .400 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 6 | Thu Nov 20 | at #14St John's | L49-97 | 2-4 | .333 | - | TNT | Carnesecca Arena · Queens, NY |
| 7 | Mon Nov 24 | at Bowling Green | L66-71 | 2-5 | .286 | - | | Stroh Center · Bowling Green, OH |
| 8 | Wed Nov 26 | vs Buffalo | L71-73 | 2-6 | .250 | - | | Sojka Pavilion · Lewisburg, PA |
| 9 | Sun Nov 30 | vs Cornell | L72-101 | 2-7 | .222 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 10 | Wed Dec 3 | at Akron | L77-97 | 2-8 | .200 | - | ESPN+ | James A. Rhodes Arena · Akron, OH |
| 11 | Sat Dec 6 | vs UMBC | L66-73 | 2-9 | .182 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 12 | Tue Dec 9 | at Rider | W51-38 | 3-9 | .250 | - | ESPN+ | Alumni Gymnasium (Rider) · Lawrenceville, NJ |
| 13 | Sat Dec 20 | at Iowa | L39-94 | 3-10 | .231 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 14 | Wed Dec 31 | at Holy Cross | L58-65 | 3-11 | .214 | - | ESPN+ | Hart Center · Worcester, MA |
| 15 | Sat Jan 3 | vs Lehigh | W72-65 | 4-11 | .267 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 16 | Wed Jan 7 | at Navy | L55-76 | 4-12 | .250 | - | ESPN+ | Alumni Hall (Navy) · Annapolis, MD |
| 17 | Sat Jan 10 | vs Loyola MD | W70-67 | 5-12 | .294 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 18 | Wed Jan 14 | vs Lafayette | W76-69 | 6-12 | .333 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 19 | Sat Jan 17 | at Colgate | L76-95 | 6-13 | .316 | - | ESPN+ | Cotterell Court · Hamilton, NY |
| 20 | Wed Jan 21 | vs Army | L84-87 (OT) | 6-14 | .300 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 21 | Sat Jan 24 | atLoyola MD | L62-67 | 6-15 | .286 | - | ESPN+ | Reitz Arena · Baltimore, MD |
| 22 | Wed Jan 28 | atLafayette | L79-81 | 6-16 | .273 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 23 | Sat Jan 31 | vs Boston Univ | W103-97 (2OT) | 7-16 | .304 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 24 | Wed Feb 4 | at American | W60-59 | 8-16 | .333 | - | ESPN+ | Bender Arena · Washington, D.C. |
| 25 | Sat Feb 7 | vsColgate | L59-78 | 8-17 | .320 | - | ESPN+ | Sojka Pavilion · Lewisburg, PA |
| 26 | Mon Feb 9 | vsNavy | L60-76 | 8-18 | .308 | - | CBSSN | Sojka Pavilion · Lewisburg, PA |
