| 1 | Mon Nov 3 | at Northwestern | L47-70 | 0-1 | .000 | - | B1G+ | Welsh-Ryan Arena · Evanston, IL |
| 2 | Thu Nov 6 | at Loyola Chicago | W73-65 | 1-1 | .500 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 3 | Sat Nov 8 | vs TBD | W94-43 | 2-1 | .667 | - | | Mercyhurst Athletic Center · Erie, PA |
| 4 | Wed Nov 12 | at Canisius | L55-58 | 2-2 | .500 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 5 | Sat Nov 15 | vs Morgan St | W86-72 | 3-2 | .600 | - | | Mercyhurst Athletic Center · Erie, PA |
| 6 | Thu Nov 20 | at Miami OH | L71-76 | 3-3 | .500 | - | ESPN+ | Millett Hall · Oxford, OH |
| 7 | Sun Nov 23 | at Marshall | L60-69 | 3-4 | .429 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 8 | Sun Nov 30 | at West Virginia | L38-70 | 3-5 | .375 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 9 | Fri Dec 5 | at Lafayette | L71-79 | 3-6 | .333 | - | ESPN+ | Kirby Sports Center · Easton, PA |
| 10 | Sun Dec 7 | vsTBD | W80-51 | 4-6 | .400 | - | | Mercyhurst Athletic Center · Erie, PA |
| 11 | Sat Dec 13 | at Davidson | L47-80 | 4-7 | .364 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 12 | Wed Dec 17 | at Syracuse | L62-76 | 4-8 | .333 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 13 | Sat Dec 20 | vs Binghamton | W82-61 | 5-8 | .385 | - | | Mercyhurst Athletic Center · Erie, PA |
| 14 | Fri Jan 2 | vs Fairleigh | L67-74 | 5-9 | .357 | - | | Mercyhurst Athletic Center · Erie, PA |
| 15 | Sun Jan 4 | vs Le Moyne | W74-60 | 6-9 | .400 | - | | Mercyhurst Athletic Center · Erie, PA |
| 16 | Thu Jan 8 | at Long Island | L58-60 | 6-10 | .375 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 17 | Sat Jan 10 | at Wagner | W70-69 | 7-10 | .412 | - | | Spiro Sports Center · Staten Island, NY |
| 18 | Sat Jan 17 | vs Stonehill | L57-62 (OT) | 7-11 | .389 | - | | Mercyhurst Athletic Center · Erie, PA |
| 19 | Mon Jan 19 | vs C Connecticut | W79-61 | 8-11 | .421 | - | | Mercyhurst Athletic Center · Erie, PA |
| 20 | Fri Jan 23 | at New Haven | W61-57 | 9-11 | .450 | - | | Jeffery P. Hazell Athletics Center |
| 21 | Sun Jan 25 | vs Chicago St | W61-59 | 10-11 | .476 | - | | Mercyhurst Athletic Center · Erie, PA |
| 22 | Thu Jan 29 | vsNew Haven | W70-51 | 11-11 | .500 | - | | Mercyhurst Athletic Center · Erie, PA |
| 23 | Sat Jan 31 | atChicago St | L74-78 | 11-12 | .478 | - | | Jones Convocation Center · Chicago, IL |
| 24 | Thu Feb 5 | vs St Francis PA | W98-89 (OT) | 12-12 | .500 | - | ESPN+ | Mercyhurst Athletic Center · Erie, PA |
| 25 | Sat Feb 7 | atFairleigh | L52-55 | 12-13 | .480 | - | | Stratis Arena at the Rothman Center · Teaneck, NJ |
