| 1 | Mon Nov 3 | at DePaul | L62-92 | 0-1 | .000 | - | ESPN+ | Wintrust Arena · Chicago, IL |
| 2 | Thu Nov 6 | at Saint Louis | L86-108 | 0-2 | .000 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 3 | Tue Nov 11 | at Butler | L66-98 | 0-3 | .000 | - | ESPN+ | Hinkle Fieldhouse · Indianapolis, IN |
| 4 | Sat Nov 15 | vs UIC | L63-67 | 0-4 | .000 | - | | Jones Convocation Center · Chicago, IL |
| 5 | Tue Nov 18 | at Minnesota | L54-66 | 0-5 | .000 | - | B1G+ | Williams Arena · Minneapolis, MN |
| 6 | Thu Nov 20 | at Iowa | L54-93 | 0-6 | .000 | - | B1G+ | Carver-Hawkeye Arena · Iowa City, IA |
| 7 | Tue Nov 25 | at Purdue FW | L77-90 | 0-7 | .000 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 8 | Fri Nov 28 | at Youngstown St | L64-87 | 0-8 | .000 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 9 | Mon Dec 1 | vs TBD | W85-62 | 1-8 | .111 | - | | Jones Convocation Center · Chicago, IL |
| 10 | Sat Dec 6 | at Illinois St | L53-95 | 1-9 | .100 | - | ESPN+ | Redbird Arena · Normal, IL |
| 11 | Sun Dec 14 | at Loyola Chicago | W84-75 | 2-9 | .182 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 12 | Tue Dec 16 | at Bowling Green | L55-76 | 2-10 | .167 | - | ESPN+ | Stroh Center · Bowling Green, OH |
| 13 | Sat Dec 20 | at Indiana | L58-78 | 2-11 | .154 | - | B1G+ | Simon Skjodt Assembly Hall · Bloomington, IN |
| 14 | Fri Jan 2 | vs Wagner | L72-79 | 2-12 | .143 | - | | Jones Convocation Center · Chicago, IL |
| 15 | Sun Jan 4 | vs Long Island | L55-74 | 2-13 | .133 | - | | Jones Convocation Center · Chicago, IL |
| 16 | Thu Jan 8 | at Fairleigh | L63-70 | 2-14 | .125 | - | | Stratis Arena at the Rothman Center · Teaneck, NJ |
| 17 | Sat Jan 10 | at Stonehill | L82-85 (OT) | 2-15 | .118 | - | | placeholder · sf, ca |
| 18 | Sat Jan 17 | vs Le Moyne | L57-72 | 2-16 | .111 | - | | Jones Convocation Center · Chicago, IL |
| 19 | Mon Jan 19 | vs New Haven | L56-62 | 2-17 | .105 | - | | Jones Convocation Center · Chicago, IL |
| 20 | Fri Jan 23 | at St Francis PA | L60-81 | 2-18 | .100 | - | | DeGol Arena · Loretto, PA |
| 21 | Sun Jan 25 | at Mercyhurst | L59-61 | 2-19 | .095 | - | | Mercyhurst Athletic Center · Erie, PA |
| 22 | Sat Jan 31 | vsMercyhurst | W78-74 | 3-19 | .136 | - | | Jones Convocation Center · Chicago, IL |
| 23 | Thu Feb 5 | at C Connecticut | L67-78 | 3-20 | .130 | - | | William H. Detrick Gymnasium · New Britain, CT |
| 24 | Sat Feb 7 | atNew Haven | W63-57 | 4-20 | .167 | - | | Jeffery P. Hazell Athletics Center |
| 25 | Mon Feb 9 | vsSt Francis PA | W80-75 | 5-20 | .200 | - | | Jones Convocation Center · Chicago, IL |
