| 1 | Mon Nov 3 | at Oklahoma | L66-102 | 0-1 | .000 | - | SECN+ | Lloyd Noble Center · Norman, OK |
| 2 | Thu Nov 6 | at TCU | L63-104 | 0-2 | .000 | - | TNT | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 3 | Tue Nov 11 | vs Mount St Mary | L66-74 | 0-3 | .000 | - | | DeGol Arena · Loretto, PA |
| 4 | Tue Nov 18 | at Lehigh | L62-79 | 0-4 | .000 | - | ESPN+ | Stabler Arena · Bethlehem, PA |
| 5 | Mon Nov 24 | at Belmont | L57-94 | 0-5 | .000 | - | | Alico Arena · Fort Myers, FL |
| 6 | Wed Nov 26 | at Troy | L64-74 | 0-6 | .000 | - | | Alico Arena · Fort Myers, FL |
| 7 | Sat Nov 29 | vs TBD | W85-60 | 1-6 | .143 | - | | DeGol Arena · Loretto, PA |
| 8 | Mon Dec 1 | at Xavier | L74-96 | 1-7 | .125 | - | truTV | Cintas Center · Cincinnati, OH |
| 9 | Wed Dec 3 | vsTBD | W100-41 | 2-7 | .222 | - | | DeGol Arena · Loretto, PA |
| 10 | Sun Dec 7 | at Radford | L56-89 | 2-8 | .200 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 11 | Sun Dec 14 | at Temple | L67-95 | 2-9 | .182 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 12 | Wed Dec 17 | at #23Florida | L61-102 | 2-10 | .167 | - | SEC Network | O'Connell Center · Gainesville, FL |
| 13 | Sat Dec 20 | vs Robert Morris | L70-79 | 2-11 | .154 | - | | DeGol Arena · Loretto, PA |
| 14 | Fri Jan 2 | vs Le Moyne | L58-84 | 2-12 | .143 | - | | DeGol Arena · Loretto, PA |
| 15 | Sun Jan 4 | vs Fairleigh | W85-82 | 3-12 | .200 | - | | DeGol Arena · Loretto, PA |
| 16 | Thu Jan 8 | at Wagner | W71-69 | 4-12 | .250 | - | | Spiro Sports Center · Staten Island, NY |
| 17 | Sat Jan 10 | at Long Island | L63-67 | 4-13 | .235 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 18 | Sat Jan 17 | vs C Connecticut | L90-98 | 4-14 | .222 | - | | DeGol Arena · Loretto, PA |
| 19 | Mon Jan 19 | vs Stonehill | W63-61 | 5-14 | .263 | - | | DeGol Arena · Loretto, PA |
| 20 | Fri Jan 23 | vs Chicago St | W81-60 | 6-14 | .300 | - | | DeGol Arena · Loretto, PA |
| 21 | Sun Jan 25 | at New Haven | PPD | 6-18 | .250 | - | | Jeffery P. Hazell Athletics Center |
| 22 | Sat Jan 31 | vsNew Haven | L69-81 | 6-15 | .286 | - | | DeGol Arena · Loretto, PA |
| 23 | Thu Feb 5 | at Mercyhurst | L89-98 (OT) | 6-16 | .273 | - | ESPN+ | Mercyhurst Athletic Center · Erie, PA |
| 24 | Sat Feb 7 | atLe Moyne | L84-86 | 6-17 | .261 | - | | Ted Grant Court · Syracuse, NY |
| 25 | Mon Feb 9 | atChicago St | L75-80 | 6-18 | .250 | - | | Jones Convocation Center · Chicago, IL |
