| 1 | Mon Nov 3 | vs St Francis PA | W102-66 | 1-0 | 1.000 | - | SECN+ | Lloyd Noble Center · Norman, OK |
| 2 | Sat Nov 8 | at #21Gonzaga | L68-83 | 1-1 | .500 | - | ESPN2 | McCarthey Athletic Center · Spokane, WA |
| 3 | Tue Nov 11 | vs AR-Pine Bluff | W95-69 | 2-1 | .667 | - | SECN+ | Lloyd Noble Center · Norman, OK |
| 4 | Sat Nov 15 | at Nebraska | L99-105 | 2-2 | .500 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 5 | Thu Nov 20 | vs Oral Roberts | W95-71 | 3-2 | .600 | - | SECN+ | Lloyd Noble Center · Norman, OK |
| 6 | Sun Nov 23 | vs Alcorn St | W72-53 | 4-2 | .667 | - | SECN+ | Lloyd Noble Center · Norman, OK |
| 7 | Fri Nov 28 | at Marquette | W75-74 | 5-2 | .714 | - | NBC | Credit Union 1 Arena · Chicago, IL |
| 8 | Tue Dec 2 | at Wake Forest | W86-68 | 6-2 | .750 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 9 | Sat Dec 6 | at Arizona St | L70-86 | 6-3 | .667 | - | CBSSN | Mortgage Matchup Center · Phoenix, AZ |
| 10 | Sat Dec 13 | at Oklahoma St | W85-76 | 7-3 | .700 | - | FOX | Gallagher-Iba Arena · Stillwater, OK |
| 11 | Tue Dec 16 | vs Kansas City | W89-67 | 8-3 | .727 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 12 | Mon Dec 22 | vs Stetson | W107-54 | 9-3 | .750 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 13 | Mon Dec 29 | vs Miss Valley St | W93-69 | 10-3 | .769 | - | SECN+ | Lloyd Noble Center · Norman, OK |
| 14 | Sat Jan 3 | vs Ole Miss | W86-70 | 11-3 | .786 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 15 | Wed Jan 7 | at Mississippi St | L53-72 | 11-4 | .733 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 16 | Sat Jan 10 | at Texas A&M | L76-83 | 11-5 | .688 | - | SEC Network | Reed Arena · College Station, TX |
| 17 | Tue Jan 13 | vs #19Florida | L79-96 | 11-6 | .647 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 18 | Sat Jan 17 | vs #18Alabama | L81-83 | 11-7 | .611 | - | SEC Network | Lloyd Noble Center · Norman, OK |
| 19 | Tue Jan 20 | at South Carolina | L76-85 | 11-8 | .579 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 20 | Sat Jan 24 | at Missouri | L87-88 (OT) | 11-9 | .550 | - | ESPN2 | Mizzou Arena · Columbia, MO |
| 21 | Tue Jan 27 | vs #15Arkansas | L79-83 | 11-10 | .524 | - | ESPN | Lloyd Noble Center · Norman, OK |
| 22 | Sat Jan 31 | vs Texas | L69-79 | 11-11 | .500 | - | ESPN2 | Lloyd Noble Center · Norman, OK |
| 23 | Wed Feb 4 | at Kentucky | L78-94 | 11-12 | .478 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 24 | Sat Feb 7 | at #15Vanderbilt | W92-91 | 12-12 | .500 | - | SEC Network | Memorial Gymnasium (TN) · Nashville, TN |
Georgia
Tennessee
Auburn
LSU