| 1 | Tue Nov 4 | at Florida St | L76-108 | 0-1 | .000 | - | ACC Extra | Donald L. Tucker Center · Tallahassee, FL |
| 2 | Thu Nov 6 | at South Alabama | L70-76 | 0-2 | .000 | - | ESPN+ | Mitchell Center · Mobile, AL |
| 3 | Sat Nov 8 | at Minnesota | L50-95 | 0-3 | .000 | - | Peacock | Williams Arena · Minneapolis, MN |
| 4 | Tue Nov 11 | at Maryland | L64-84 | 0-4 | .000 | - | B1G+ | XFINITY Center · College Park, MD |
| 5 | Thu Nov 13 | at Howard | L64-72 | 0-5 | .000 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 6 | Tue Nov 18 | at LSU | L81-107 | 0-6 | .000 | - | SECN+ | Pete Maravich Assembly Center · Baton Rouge, LA |
| 7 | Sun Nov 23 | at Oklahoma | L53-72 | 0-7 | .000 | - | SECN+ | Lloyd Noble Center · Norman, OK |
| 8 | Fri Nov 28 | vs Indiana St | W81-74 | 1-7 | .125 | - | | Hulman Center · Terre Haute, IN |
| 9 | Sat Nov 29 | at Louisiana Tech | L58-83 | 1-8 | .111 | - | ESPN+ | Thomas Assembly Center · Ruston, LA |
| 10 | Wed Dec 3 | at #10Iowa State | L68-132 | 1-9 | .100 | - | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 11 | Fri Dec 19 | at Baylor | L56-113 | 1-10 | .091 | - | ESPN+ | Ferrell Center · Waco, TX |
| 12 | Mon Dec 29 | at Ole Miss | L43-79 | 1-11 | .083 | - | SEC Network | SJB Pavilion · Oxford, MS |
| 13 | Sat Jan 3 | at Jackson St | L86-89 | 1-12 | .077 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 14 | Sat Jan 10 | at Alabama A&M | W64-62 | 2-12 | .143 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 15 | Mon Jan 12 | at Alabama St | L66-81 | 2-13 | .133 | - | | Dunn-Oliver Acadome · Montgomery, AL |
| 16 | Sat Jan 17 | vs Texas So | L71-72 | 2-14 | .125 | - | | Davey L. Whitney Complex · Lorman, MS |
| 17 | Mon Jan 19 | vs Prairie View | W76-75 | 3-14 | .176 | - | | Davey L. Whitney Complex · Lorman, MS |
| 18 | Sat Jan 24 | at FAMU | L58-66 | 3-15 | .167 | - | | Al Lawson Center · Tallahassee, FL |
| 19 | Mon Jan 26 | at Bethune | L73-82 | 3-16 | .158 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 20 | Sat Jan 31 | vs Southern | W78-73 | 4-16 | .200 | - | | Davey L. Whitney Complex · Lorman, MS |
| 21 | Mon Feb 2 | vs Grambling | L50-74 | 4-17 | .190 | - | | Davey L. Whitney Complex · Lorman, MS |
| 22 | Sat Feb 7 | at AR-Pine Bluff | L77-84 | 4-18 | .182 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
| 23 | Mon Feb 9 | at Miss Valley St | W74-66 | 5-18 | .217 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
