| 1 | Mon Nov 3 | at #21Gonzaga | L43-98 | 0-1 | .000 | - | ESPN+ | McCarthey Athletic Center · Spokane, WA |
| 2 | Thu Nov 6 | at Texas A&M | L70-104 | 0-2 | .000 | - | SECN+ | Reed Arena · College Station, TX |
| 3 | Wed Nov 12 | vs Samford | L90-93 (OT) | 0-3 | .000 | - | | H&PE Arena · Houston, TX |
| 4 | Sat Nov 15 | at Texas St | L67-77 | 0-4 | .000 | - | ESPN+ | Strahan Arena · San Marcos, TX |
| 5 | Thu Nov 20 | at Vanderbilt | L74-109 | 0-5 | .000 | - | SECN+ | Memorial Gymnasium (TN) · Nashville, TN |
| 6 | Wed Nov 26 | vs TBD | W102-44 | 1-5 | .167 | - | | H&PE Arena · Houston, TX |
| 7 | Sat Dec 6 | vs Sam Houston | L70-82 | 1-6 | .143 | - | YouTube | H&PE Arena · Houston, TX |
| 8 | Sun Dec 14 | at Minnesota | L53-89 | 1-7 | .125 | - | BTN | Williams Arena · Minneapolis, MN |
| 9 | Wed Dec 17 | at NC State | L72-108 | 1-8 | .111 | - | ACC Extra | PNC Arena · Raleigh, NC |
| 10 | Mon Dec 22 | vs Abilene Chrstn | L68-75 | 1-9 | .100 | - | YouTube | H&PE Arena · Houston, TX |
| 11 | Tue Dec 30 | vsTBD | W80-56 | 2-9 | .182 | - | YouTube | H&PE Arena · Houston, TX |
| 12 | Sat Jan 3 | at Southern | L73-84 | 2-10 | .167 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 13 | Mon Jan 5 | at Grambling | L67-84 | 2-11 | .154 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 14 | Sat Jan 10 | vs AR-Pine Bluff | L66-74 | 2-12 | .143 | - | | H&PE Arena · Houston, TX |
| 15 | Mon Jan 12 | vs Miss Valley St | W84-51 | 3-12 | .200 | - | | H&PE Arena · Houston, TX |
| 16 | Sat Jan 17 | at Alcorn St | W72-71 | 4-12 | .250 | - | | Davey L. Whitney Complex · Lorman, MS |
| 17 | Mon Jan 19 | at Jackson St | L89-94 | 4-13 | .235 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 18 | Sat Jan 24 | vs Alabama A&M | W89-74 | 5-13 | .278 | - | | H&PE Arena · Houston, TX |
| 19 | Tue Jan 27 | vs Alabama St | W96-64 | 6-13 | .316 | - | | H&PE Arena · Houston, TX |
| 20 | Sat Jan 31 | at Prairie View | L78-85 | 6-14 | .300 | - | | William Nicks Building · Prairie View, TX |
| 21 | Sat Feb 7 | at FAMU | W62-57 | 7-14 | .333 | - | | Al Lawson Center · Tallahassee, FL |
| 22 | Mon Feb 9 | at Bethune | L69-79 (OT) | 7-15 | .318 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
