| 1 | Mon Nov 3 | at #17Illinois | L55-113 | 0-1 | .000 | - | BTN | State Farm Center · Champaign, IL |
| 2 | Thu Nov 6 | at #11Louisville | L70-106 | 0-2 | .000 | - | ACC Extra | KFC Yum! Center · Louisville, KY |
| 3 | Sat Nov 15 | at Louisiana Tech | L51-68 | 0-3 | .000 | - | ESPN+ | Thomas Assembly Center · Ruston, LA |
| 4 | Wed Nov 19 | at #22Auburn | L66-112 | 0-4 | .000 | - | SEC Network | Neville Arena · Auburn, AL |
| 5 | Fri Nov 21 | at #21Arkansas | L61-115 | 0-5 | .000 | - | SECN+ | Bud Walton Arena · Fayetteville, AR |
| 6 | Sun Nov 23 | vs Winthrop | L62-80 | 0-6 | .000 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 7 | Fri Nov 28 | at Louisiana | W51-45 | 1-6 | .143 | - | ESPN+ | Cajundome · Lafayette, LA |
| 8 | Tue Dec 2 | at Kennesaw St | L73-88 | 1-7 | .125 | - | ESPN+ | KSU Convocation Center · Kennesaw, GA |
| 9 | Wed Dec 10 | at #7Houston | L38-80 | 1-8 | .111 | - | ESPN+ | Fertitta Center · Houston, TX |
| 10 | Sat Dec 13 | at Northwestern | L53-93 | 1-9 | .100 | - | BTN | Welsh-Ryan Arena · Evanston, IL |
| 11 | Thu Dec 18 | vs Hampton | L77-84 | 1-10 | .091 | - | ESPNU | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 12 | Fri Dec 19 | vs Norfolk St | L72-82 | 1-11 | .083 | - | ESPNU | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 13 | Mon Dec 29 | at TCU | L64-115 | 1-12 | .077 | - | ESPN+ | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 14 | Sat Jan 3 | vs Alcorn St | W89-86 | 2-12 | .143 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 15 | Sat Jan 10 | at Alabama St | W75-64 | 3-12 | .200 | - | ESPNU | Dunn-Oliver Acadome · Montgomery, AL |
| 16 | Mon Jan 12 | at Alabama A&M | L91-100 | 3-13 | .188 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 17 | Sat Jan 17 | vs Prairie View | W82-78 | 4-13 | .235 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 18 | Mon Jan 19 | vs Texas So | W94-89 | 5-13 | .278 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 19 | Sat Jan 24 | at Bethune | L48-85 | 5-14 | .263 | - | ESPNU | Moore Gymnasium (FL) · Daytona Beach, FL |
| 20 | Mon Jan 26 | at FAMU | W66-65 | 6-14 | .300 | - | | Al Lawson Center · Tallahassee, FL |
| 21 | Sat Jan 31 | vs Grambling | L66-69 | 6-15 | .286 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 22 | Mon Feb 2 | vs Southern | L91-96 (OT) | 6-16 | .273 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 23 | Sat Feb 7 | at Miss Valley St | W97-81 | 7-16 | .304 | - | | Robert W. Harrison HPER Complex · Itta Bena, MS |
| 24 | Mon Feb 9 | at AR-Pine Bluff | L63-84 | 7-17 | .292 | - | | H. O. Clemmons Arena · Pine Bluff, AR |
