| 1 | Mon Nov 3 | vs Queens | W81-74 | 1-0 | 1.000 | - | YouTube | Winthrop Coliseum · Rock Hill, SC |
| 2 | Fri Nov 7 | at George Mason | L90-96 | 1-1 | .500 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 3 | Tue Nov 11 | at Coast Car | L66-72 | 1-2 | .333 | - | ESPN+ | The HTC Center · Conway, SC |
| 4 | Sat Nov 15 | vs Mercer | W105-69 | 2-2 | .500 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 5 | Tue Nov 18 | at #21Arkansas | L83-84 | 2-3 | .400 | - | SECN+ | Bud Walton Arena · Fayetteville, AR |
| 6 | Sun Nov 23 | at Jackson St | W80-62 | 3-3 | .500 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 7 | Tue Nov 25 | at Nebraska | L73-80 | 3-4 | .429 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 8 | Sat Nov 29 | vs SC State | W101-79 | 4-4 | .500 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 9 | Tue Dec 2 | at Long Island | W94-92 (OT) | 5-4 | .556 | - | | Steinberg Wellness Center · Brooklyn, NY |
| 10 | Sat Dec 6 | vsCoast Car | L84-88 | 5-5 | .500 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 11 | Tue Dec 9 | vs TBD | W111-62 | 6-5 | .545 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 12 | Sat Dec 13 | vsTBD | W101-55 | 7-5 | .583 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 13 | Thu Dec 18 | at North Dakota | L88-90 | 7-6 | .538 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 14 | Sun Dec 21 | vsTBD | W107-41 | 8-6 | .571 | - | | Winthrop Coliseum · Rock Hill, SC |
| 15 | Sun Dec 28 | at #15Texas Tech | L57-87 | 8-7 | .533 | - | TNT | United Supermarkets Arena · Lubbock, TX |
| 16 | Wed Dec 31 | at Longwood | L70-82 | 8-8 | .500 | - | ESPN+ | Willett Hall · Farmville, VA |
| 17 | Sat Jan 3 | vs Gardner-Webb | W88-77 | 9-8 | .529 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 18 | Wed Jan 7 | vs Charleston So | W81-77 | 10-8 | .556 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 19 | Sat Jan 10 | at SC Upstate | W71-50 | 11-8 | .579 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 20 | Wed Jan 14 | vs High Point | W92-75 | 12-8 | .600 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 21 | Sat Jan 17 | at UNC Asheville | W69-67 | 13-8 | .619 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 22 | Wed Jan 21 | vs Radford | W76-75 | 14-8 | .636 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 23 | Sat Jan 24 | at Presbyterian | W82-72 | 15-8 | .652 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 24 | Sat Jan 31 | vsUNC Asheville | W84-71 | 16-8 | .667 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 25 | Wed Feb 4 | atRadford | W80-78 | 17-8 | .680 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 26 | Sat Feb 7 | vsLongwood | W79-74 | 18-8 | .692 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
