| 1 | Mon Nov 3 | vs W Illinois | W80-75 | 1-0 | 1.000 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 2 | Fri Nov 7 | vs TBD | W99-61 | 2-0 | 1.000 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 3 | Tue Nov 11 | at #18UNC | L74-89 | 2-1 | .667 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 4 | Sat Nov 15 | vs Wright St | L59-92 | 2-2 | .500 | - | | Donald N. Dedmon Center · Radford, VA |
| 5 | Sun Nov 16 | at Cleveland St | L82-87 | 2-3 | .400 | - | | Wolstein Center · Cleveland, OH |
| 6 | Tue Nov 18 | at South Carolina | L58-87 | 2-4 | .333 | - | SECN+ | Colonial Life Arena · Columbia, SC |
| 7 | Fri Nov 21 | vs UNC Wilmington | L73-81 | 2-5 | .286 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 8 | Mon Nov 24 | at SMU | L72-89 | 2-6 | .250 | - | ACC Extra | Moody Coliseum · Dallas, TX |
| 9 | Sat Nov 29 | vsTBD | W102-75 | 3-6 | .333 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 10 | Wed Dec 3 | vs Southern Miss | L75-82 | 3-7 | .300 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 11 | Sun Dec 7 | vs St Francis PA | W89-56 | 4-7 | .364 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 12 | Sun Dec 14 | vs Coppin St | W107-77 | 5-7 | .417 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 13 | Thu Dec 18 | at William & Mary | L83-96 | 5-8 | .385 | - | | Kaplan Arena · Williamsburg, VA |
| 14 | Sun Dec 21 | vs VMI | W97-90 | 6-8 | .429 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 15 | Sun Dec 28 | vsTBD | W87-44 | 7-8 | .467 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 16 | Wed Dec 31 | at SC Upstate | W76-69 | 8-8 | .500 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 17 | Wed Jan 7 | vs Presbyterian | W80-61 | 9-8 | .529 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 18 | Sat Jan 10 | vs UNC Asheville | L72-91 | 9-9 | .500 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 19 | Wed Jan 14 | at Gardner-Webb | W89-80 | 10-9 | .526 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 20 | Sat Jan 17 | vs Longwood | W85-83 | 11-9 | .550 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 21 | Wed Jan 21 | at Winthrop | L75-76 | 11-10 | .524 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 22 | Fri Jan 23 | vs High Point | L83-93 | 11-11 | .500 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 23 | Thu Jan 29 | at Charleston So | W84-75 | 12-11 | .522 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 24 | Sat Jan 31 | atPresbyterian | W93-84 (2OT) | 13-11 | .542 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 25 | Wed Feb 4 | vsWinthrop | L78-80 | 13-12 | .520 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 26 | Sat Feb 7 | atHigh Point | L77-86 | 13-13 | .500 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
