| 1 | Mon Nov 3 | at Buffalo | L79-85 | 0-1 | .000 | - | ESPN+ | Alumni Arena · Buffalo, NY |
| 2 | Thu Nov 6 | vs TBD | W93-57 | 1-1 | .500 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 3 | Sun Nov 9 | at South Carolina | L79-83 (OT) | 1-2 | .333 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 4 | Thu Nov 13 | at Grambling | L70-75 | 1-3 | .250 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 5 | Tue Nov 18 | vsTBD | W82-59 | 2-3 | .400 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 6 | Sat Nov 22 | vs North Florida | W92-83 | 3-3 | .500 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 7 | Sun Nov 23 | vs UT Martin | W70-60 | 4-3 | .571 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 8 | Wed Dec 3 | at Radford | W82-75 | 5-3 | .625 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 9 | Sat Dec 6 | at Miami | L64-88 | 5-4 | .556 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 10 | Mon Dec 8 | vsGrambling | W68-60 | 6-4 | .600 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 11 | Sat Dec 13 | at Ole Miss | L67-71 | 6-5 | .545 | - | SECN+ | SJB Pavilion · Oxford, MS |
| 12 | Thu Dec 18 | vs Louisiana | W62-54 | 7-5 | .583 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 13 | Sat Dec 20 | vs Arkansas St | L86-93 | 7-6 | .538 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 14 | Mon Dec 29 | at LSU | L62-90 | 7-7 | .500 | - | SECN+ | Pete Maravich Assembly Center · Baton Rouge, LA |
| 15 | Thu Jan 1 | at UL Monroe | W87-73 | 8-7 | .533 | - | ESPN+ | Fant-Ewing Coliseum · Monroe, LA |
| 16 | Sat Jan 3 | atLouisiana | W74-67 | 9-7 | .563 | - | ESPN+ | Cajundome · Lafayette, LA |
| 17 | Thu Jan 8 | vs Texas St | W80-70 (OT) | 10-7 | .588 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 18 | Sat Jan 10 | vsUL Monroe | W70-60 | 11-7 | .611 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 19 | Wed Jan 14 | at Troy | L65-91 | 11-8 | .579 | - | ESPN+ | Trojan Arena · Troy, AL |
| 20 | Sat Jan 17 | atTexas St | L67-74 | 11-9 | .550 | - | ESPN+ | Strahan Arena · San Marcos, TX |
| 21 | Thu Jan 22 | at Georgia St | L62-69 | 11-10 | .524 | - | ESPN+ | GSU Convocation Center · Atlanta, GA |
| 22 | Sat Jan 24 | at Coast Car | L67-85 | 11-11 | .500 | - | ESPN+ | The HTC Center · Conway, SC |
| 23 | Thu Jan 29 | vs Appalachian St | L63-70 | 11-12 | .478 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 24 | Sat Jan 31 | vs JMU | W73-65 | 12-12 | .500 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
| 25 | Wed Feb 4 | at Marshall | L77-81 | 12-13 | .480 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 26 | Sat Feb 7 | vs Kent State | W66-65 | 13-13 | .500 | - | ESPN+ | Reed Green Coliseum · Hattiesburg, MS |
South Alabama
Old Dominion