| 1 | Tue Nov 4 | at UNLV | W86-81 | 1-0 | 1.000 | - | | Thomas & Mack Center · Las Vegas, NV |
| 2 | Sun Nov 9 | vs TBD | W97-42 | 2-0 | 1.000 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 3 | Wed Nov 12 | at Bradley | W78-67 | 3-0 | 1.000 | - | ESPN+ | Carver Arena · Peoria, IL |
| 4 | Tue Nov 18 | at Florida St | L73-87 | 3-1 | .750 | - | ACC Extra | Donald L. Tucker Center · Tallahassee, FL |
| 5 | Sat Nov 22 | at Prairie View | W69-68 | 4-1 | .800 | - | | William Nicks Building · Prairie View, TX |
| 6 | Sun Nov 23 | at Southern Miss | L60-70 | 4-2 | .667 | - | | Reed Green Coliseum · Hattiesburg, MS |
| 7 | Tue Nov 25 | vsTBD | W75-50 | 5-2 | .714 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 8 | Tue Dec 2 | vs Charleston So | W73-56 | 6-2 | .750 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 9 | Sun Dec 7 | vs Alabama St | W74-64 | 7-2 | .778 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 10 | Wed Dec 10 | at S Illinois | L54-83 | 7-3 | .700 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 11 | Sun Dec 14 | vsTBD | W96-52 | 8-3 | .727 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 12 | Thu Dec 18 | at Tennessee St | L71-78 | 8-4 | .667 | - | ESPN+ | Gentry Center · Nashville, TN |
| 13 | Sat Dec 20 | at Tennessee Tech | W86-62 | 9-4 | .692 | - | ESPN+ | Hooper Eblen Center · Cookeville, TN |
| 14 | Thu Jan 1 | vs W Illinois | W67-60 | 10-4 | .714 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 15 | Sat Jan 3 | vs E Illinois | W65-61 | 11-4 | .733 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 16 | Thu Jan 8 | at Morehead St | W76-68 | 12-4 | .750 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 17 | Sat Jan 10 | at So Indiana | W73-56 | 13-4 | .765 | - | ESPN+ | Screaming Eagles Arena · Evansville, IN |
| 18 | Thu Jan 15 | vs SIUE | W65-59 | 14-4 | .778 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 19 | Sat Jan 17 | vs Lindenwood | W69-55 | 15-4 | .789 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 20 | Tue Jan 20 | at SE Missouri St | L50-66 | 15-5 | .750 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 21 | Thu Jan 29 | atE Illinois | W76-68 | 16-5 | .762 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 22 | Sat Jan 31 | atW Illinois | W84-44 | 17-5 | .773 | - | ESPN+ | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 23 | Tue Feb 3 | vs Little Rock | W55-52 | 18-5 | .783 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 24 | Thu Feb 5 | vsSo Indiana | W76-54 | 19-5 | .792 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 25 | Sat Feb 7 | vsMorehead St | L55-61 | 19-6 | .760 | - | ESPNU | Kathleen and Tom Elam Center · Martin, TN |
