| 1 | Mon Nov 3 | vs TBD | W89-84 | 1-0 | 1.000 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 2 | Fri Nov 7 | at Wake Forest | L65-81 | 1-1 | .500 | - | ACC Extra | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 3 | Sun Nov 9 | at Georgia | L81-120 | 1-2 | .333 | - | SECN+ | Stegeman Coliseum · Athens, GA |
| 4 | Tue Nov 11 | at Clemson | L56-83 | 1-3 | .250 | - | ACC Extra | Littlejohn Coliseum · Clemson, SC |
| 5 | Sun Nov 16 | vsTBD | W121-51 | 2-3 | .400 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 6 | Fri Nov 21 | at ETSU | L62-77 | 2-4 | .333 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 7 | Sat Nov 22 | at UL Monroe | W83-80 | 3-4 | .429 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 8 | Sat Nov 29 | at IU Indy | L80-85 | 3-5 | .375 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 9 | Tue Dec 2 | at Murray St | L52-84 | 3-6 | .333 | - | ESPN+ | CFSB Center · Murray, KY |
| 10 | Sat Dec 6 | at Presbyterian | L72-80 | 3-7 | .300 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 11 | Tue Dec 16 | vs Little Rock | W78-64 | 4-7 | .364 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 12 | Sat Dec 20 | at So Indiana | W64-60 (OT) | 5-7 | .417 | - | ESPN+ | Screaming Eagles Arena · Evansville, IN |
| 13 | Sun Dec 28 | vsTBD | W115-65 | 6-7 | .462 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 14 | Thu Jan 1 | at Lindenwood | L64-77 | 6-8 | .429 | - | ESPN+ | placeholder · sf, ca |
| 15 | Sat Jan 3 | at SIUE | W73-72 | 7-8 | .467 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 16 | Thu Jan 8 | vs UT Martin | L68-76 | 7-9 | .438 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 17 | Sat Jan 10 | vs SE Missouri St | W71-69 | 8-9 | .471 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 18 | Thu Jan 15 | at Tennessee St | L100-105 (OT) | 8-10 | .444 | - | ESPN+ | Gentry Center · Nashville, TN |
| 19 | Sat Jan 17 | at Tennessee Tech | W76-70 | 9-10 | .474 | - | ESPN+ | Hooper Eblen Center · Cookeville, TN |
| 20 | Thu Jan 22 | vs W Illinois | W71-66 | 10-10 | .500 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 21 | Sat Jan 24 | vs E Illinois | W73-68 | 11-10 | .524 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 22 | Thu Jan 29 | vsSIUE | W67-65 | 12-10 | .545 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 23 | Sat Jan 31 | vsLindenwood | L78-79 | 12-11 | .522 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 24 | Thu Feb 5 | atSE Missouri St | L70-82 | 12-12 | .500 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 25 | Sat Feb 7 | atUT Martin | W61-55 | 13-12 | .520 | - | ESPNU | Kathleen and Tom Elam Center · Martin, TN |
