| 1 | Mon Nov 3 | vs Omaha | W85-77 | 1-0 | 1.000 | - | YouTube | CFSB Center · Murray, KY |
| 2 | Fri Nov 7 | vs Miss Valley St | W108-60 | 2-0 | 1.000 | - | ESPN+ | CFSB Center · Murray, KY |
| 3 | Tue Nov 11 | at SMU | L91-102 | 2-1 | .667 | - | ACC Extra | Moody Coliseum · Dallas, TX |
| 4 | Sat Nov 15 | vs Nicholls | W99-79 | 3-1 | .750 | - | ESPN+ | CFSB Center · Murray, KY |
| 5 | Tue Nov 18 | vs Little Rock | W89-68 | 4-1 | .800 | - | ESPN+ | CFSB Center · Murray, KY |
| 6 | Sun Nov 23 | at MTSU | L87-90 | 4-2 | .667 | - | | Murphy Center · Murfreesboro, TN |
| 7 | Mon Nov 24 | at McNeese | L60-73 | 4-3 | .571 | - | | Legacy Center · Lake Charles, LA |
| 8 | Tue Nov 25 | at G Washington | W96-95 | 5-3 | .625 | - | | Charles E. Smith Center · Washington, D.C. |
| 9 | Tue Dec 2 | vs Morehead St | W84-52 | 6-3 | .667 | - | ESPN+ | CFSB Center · Murray, KY |
| 10 | Sat Dec 6 | vs Bellarmine | W81-68 | 7-3 | .700 | - | ESPN+ | CFSB Center · Murray, KY |
| 11 | Sat Dec 13 | at Akron | W115-100 | 8-3 | .727 | - | | James A. Rhodes Arena · Akron, OH |
| 12 | Thu Dec 18 | vs Drake | W81-72 | 9-3 | .750 | - | ESPN+ | CFSB Center · Murray, KY |
| 13 | Sun Dec 21 | at Valparaiso | W85-79 | 10-3 | .769 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 14 | Mon Dec 29 | vs S Illinois | W84-81 | 11-3 | .786 | - | ESPN+ | CFSB Center · Murray, KY |
| 15 | Thu Jan 1 | at UIC | W81-77 | 12-3 | .800 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 16 | Sun Jan 4 | vs Bradley | W86-66 | 13-3 | .813 | - | ESPN2 | CFSB Center · Murray, KY |
| 17 | Wed Jan 7 | at Evansville | W79-69 | 14-3 | .824 | - | ESPN+ | Ford Center · Evansville, IN |
| 18 | Sat Jan 10 | vsValparaiso | W92-79 | 15-3 | .833 | - | ESPN+ | CFSB Center · Murray, KY |
| 19 | Sat Jan 17 | vs Indiana St | W85-81 | 16-3 | .842 | - | ESPN+ | CFSB Center · Murray, KY |
| 20 | Wed Jan 21 | atDrake | L90-101 | 16-4 | .800 | - | CBSSN | The Knapp Center · Des Moines, IA |
| 21 | Sat Jan 24 | at Northern Iowa | L76-81 | 16-5 | .762 | - | CBSSN | McLeod Center · Cedar Falls, IA |
| 22 | Wed Jan 28 | vs Illinois St | L65-70 | 16-6 | .727 | - | ESPN+ | CFSB Center · Murray, KY |
| 23 | Sat Jan 31 | at Belmont | L86-103 | 16-7 | .696 | - | CBSSN | Curb Event Center Arena · Nashville, TN |
| 24 | Tue Feb 3 | vsUIC | W81-74 | 17-7 | .708 | - | ESPN+ | CFSB Center · Murray, KY |
| 25 | Fri Feb 6 | atS Illinois | W91-81 | 18-7 | .720 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 26 | Mon Feb 9 | vsNorthern Iowa | L60-89 | 18-8 | .692 | - | CBSSN | CFSB Center · Murray, KY |
