| 1 | Mon Nov 3 | at Georgia | L59-104 | 0-1 | .000 | - | SECN+ | Stegeman Coliseum · Athens, GA |
| 2 | Sat Nov 8 | at Kansas St | L71-98 | 0-2 | .000 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 3 | Wed Nov 12 | vs TBD | W94-55 | 1-2 | .333 | - | ESPN+ | Knights Hall · Louisville, KY |
| 4 | Sat Nov 15 | vs Wofford | L86-94 | 1-3 | .250 | - | ESPN+ | Knights Hall · Louisville, KY |
| 5 | Wed Nov 19 | at Notre Dame | L79-86 | 1-4 | .200 | - | ACC Extra | Purcell Pavilion · South Bend, IN |
| 6 | Mon Nov 24 | at The Citadel | W70-58 | 2-4 | .333 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 7 | Tue Nov 25 | vs Hou Christian | W74-69 | 3-4 | .429 | - | | Knights Hall · Louisville, KY |
| 9 | Wed Dec 3 | vsTBD | W99-60 | 4-4 | .500 | - | ESPN+ | Knights Hall · Louisville, KY |
| 10 | Sat Dec 6 | at Murray St | L68-81 | 4-5 | .444 | - | ESPN+ | CFSB Center · Murray, KY |
| 11 | Sat Dec 13 | vs N Kentucky | L76-80 | 4-6 | .400 | - | ESPN+ | Knights Hall · Louisville, KY |
| 12 | Wed Dec 17 | vs Chattanooga | W79-64 | 5-6 | .455 | - | ESPN+ | Knights Hall · Louisville, KY |
| 13 | Tue Dec 23 | at Kentucky | L85-99 | 5-7 | .417 | - | SECN+ | Rupp Arena · Lexington, KY |
| 14 | Thu Jan 1 | at W Georgia | L85-87 | 5-8 | .385 | - | ESPN+ | The Coliseum · Carrollton, GA |
| 15 | Sat Jan 3 | at Queens | L76-98 | 5-9 | .357 | - | ESPN+ | Curry Arena · Charlotte, NC |
| 16 | Thu Jan 8 | vs C Arkansas | W84-78 (OT) | 6-9 | .400 | - | ESPN+ | Knights Hall · Louisville, KY |
| 17 | Sat Jan 10 | vs North Alabama | L73-82 | 6-10 | .375 | - | ESPN+ | Knights Hall · Louisville, KY |
| 18 | Thu Jan 15 | at Lipscomb | L71-81 | 6-11 | .353 | - | ESPN+ | Allen Arena · Nashville, TN |
| 19 | Sat Jan 17 | at E Kentucky | L69-89 | 6-12 | .333 | - | ESPN+ | McBrayer Arena · Richmond, KY |
| 20 | Thu Jan 22 | at Jacksonville | W77-70 | 7-12 | .368 | - | ESPN+ | Swisher Gymnasium · Jacksonville, FL |
| 21 | Sat Jan 24 | at North Florida | L114-117 (OT) | 7-13 | .350 | - | ESPN+ | UNF Arena · Jacksonville, FL |
| 22 | Wed Jan 28 | vsW Georgia | W77-74 | 8-13 | .381 | - | ESPN+ | Knights Hall · Louisville, KY |
| 23 | Sat Jan 31 | vsQueens | W78-75 | 9-13 | .409 | - | ESPN+ | Knights Hall · Louisville, KY |
| 24 | Thu Feb 5 | vs Stetson | W92-71 | 10-13 | .435 | - | ESPN+ | Knights Hall · Louisville, KY |
| 25 | Sat Feb 7 | vs FGCU | W81-65 | 11-13 | .458 | - | ESPN+ | Knights Hall · Louisville, KY |
N Illinois
Austin Peay