| 1 | Tue Nov 4 | vs Nicholls | W77-51 | 1-0 | 1.000 | #9 | SECN+ | Rupp Arena · Lexington, KY |
| 2 | Fri Nov 7 | vs Valparaiso | W107-59 | 2-0 | 1.000 | #9 | SECN+ | Rupp Arena · Lexington, KY |
| 3 | Tue Nov 11 | at #12Louisville | L88-96 | 2-1 | .667 | #9 | ESPN | KFC Yum! Center · Louisville, KY |
| 4 | Fri Nov 14 | vs E Illinois | W99-53 | 3-1 | .750 | #9 | SECN+ | Rupp Arena · Lexington, KY |
| 5 | Tue Nov 18 | vs #17Michigan St | L66-83 | 3-2 | .600 | #12 | ESPN | Rupp Arena · Lexington, KY |
| 6 | Fri Nov 21 | vs Loyola MD | W88-46 | 4-2 | .667 | #12 | SECN+ | Rupp Arena · Lexington, KY |
| 7 | Wed Nov 26 | vs Tennessee Tech | W104-54 | 5-2 | .714 | #19 | SEC Network | Rupp Arena · Lexington, KY |
| 8 | Tue Dec 2 | vs #16UNC | L64-67 | 5-3 | .625 | #18 | ESPN | Rupp Arena · Lexington, KY |
| 9 | Fri Dec 5 | vs #11Gonzaga | L59-94 | 5-4 | .556 | #18 | ESPN2 | Rupp Arena · Lexington, KY |
| 10 | Tue Dec 9 | vs NC Central | W103-67 | 6-4 | .600 | - | SEC Network | Rupp Arena · Lexington, KY |
| 11 | Sat Dec 13 | vs Indiana | W72-60 | 7-4 | .636 | - | ESPN | Rupp Arena · Lexington, KY |
| 12 | Sat Dec 20 | vs #22St John's | W78-66 | 8-4 | .667 | - | CBS | State Farm Arena · Atlanta, GA |
| 13 | Tue Dec 23 | vs Bellarmine | W99-85 | 9-4 | .692 | - | SECN+ | Rupp Arena · Lexington, KY |
| 14 | Sat Jan 3 | at #14Alabama | L74-89 | 9-5 | .643 | - | ESPN | Coleman Coliseum · Tuscaloosa, AL |
| 15 | Wed Jan 7 | vs Missouri | L68-73 | 9-6 | .600 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 16 | Sat Jan 10 | vs Mississippi St | W92-68 | 10-6 | .625 | - | SEC Network | Rupp Arena · Lexington, KY |
| 17 | Wed Jan 14 | at LSU | W75-74 | 11-6 | .647 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 18 | Sat Jan 17 | at #24Tennessee | W80-78 | 12-6 | .667 | - | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 19 | Wed Jan 21 | vs Texas | W85-80 | 13-6 | .684 | - | SEC Network | Rupp Arena · Lexington, KY |
| 20 | Sat Jan 24 | vs Ole Miss | W72-63 | 14-6 | .700 | - | ESPN | Rupp Arena · Lexington, KY |
| 21 | Tue Jan 27 | at #18Vanderbilt | L55-80 | 14-7 | .667 | - | ESPN | Memorial Gymnasium (TN) · Nashville, TN |
| 22 | Sat Jan 31 | at #15Arkansas | W85-77 | 15-7 | .682 | - | ESPN | Bud Walton Arena · Fayetteville, AR |
| 23 | Wed Feb 4 | vs Oklahoma | W94-78 | 16-7 | .696 | - | ESPN2 | Rupp Arena · Lexington, KY |
| 24 | Sat Feb 7 | vs#25Tennessee | W74-71 | 17-7 | .708 | - | ESPN | Rupp Arena · Lexington, KY |
#14Florida
Georgia
Auburn
South Carolina
Texas A&M