| 1 | Wed Nov 5 | vs North Alabama | W86-62 | 1-0 | 1.000 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 2 | Mon Nov 10 | at #16Iowa State | L80-96 | 1-1 | .500 | - | ESPNU | James H. Hilton Coliseum · Ames, IA |
| 3 | Sat Nov 15 | vs SE Louisiana | W75-68 | 2-1 | .667 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 4 | Thu Nov 20 | at Kansas St | L77-98 | 2-2 | .500 | - | Peacock | Bramlage Coliseum · Manhattan, KS |
| 5 | Fri Nov 21 | at New Mexico | L78-80 | 2-3 | .400 | - | Peacock | The Pit · Albuquerque, NM |
| 6 | Mon Nov 24 | vs New Orleans | W81-78 (OT) | 3-3 | .500 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 7 | Fri Nov 28 | vs SMU | L81-87 (OT) | 3-4 | .429 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 8 | Wed Dec 3 | at Georgia Tech | W85-73 | 4-4 | .500 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 9 | Sun Dec 7 | vs San Francisco | L62-65 | 4-5 | .444 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 10 | Sat Dec 13 | at Utah | W82-74 | 5-5 | .500 | - | ESPNU | Delta Center · Salt Lake City, UT |
| 11 | Tue Dec 16 | vs Long Island | W87-83 | 6-5 | .545 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 12 | Sat Dec 20 | vs Memphis | W71-66 | 7-5 | .583 | - | ESPN | Humphrey Coliseum · Starkville, MS |
| 13 | Mon Dec 29 | vs Alabama St | W94-56 | 8-5 | .615 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 14 | Sat Jan 3 | at Texas | W101-98 (OT) | 9-5 | .643 | - | SEC Network | Moody Center · Austin, TX |
| 15 | Wed Jan 7 | vs Oklahoma | W72-53 | 10-5 | .667 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 16 | Sat Jan 10 | at Kentucky | L68-92 | 10-6 | .625 | - | SEC Network | Rupp Arena · Lexington, KY |
| 17 | Tue Jan 13 | vs #18Alabama | L82-97 | 10-7 | .588 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 18 | Sat Jan 17 | vs Ole Miss | L67-68 | 10-8 | .556 | - | SEC Network | Humphrey Coliseum · Starkville, MS |
| 19 | Wed Jan 21 | at Texas A&M | L68-88 | 10-9 | .526 | - | SEC Network | Reed Arena · College Station, TX |
| 20 | Sat Jan 24 | vs #15Vanderbilt | L56-88 | 10-10 | .500 | - | SECN+ | Humphrey Coliseum · Starkville, MS |
| 21 | Wed Jan 28 | at LSU | W80-66 | 11-10 | .524 | - | SECN+ | Pete Maravich Assembly Center · Baton Rouge, LA |
| 22 | Sat Jan 31 | at Missouri | L79-84 | 11-11 | .500 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 23 | Sat Feb 7 | vs #21Arkansas | L68-88 | 11-12 | .478 | - | ESPN2 | Humphrey Coliseum · Starkville, MS |
Tennessee
Auburn
South Carolina
#14Florida
Georgia