| 1 | Tue Nov 4 | vs UNC Greensboro | W93-64 | 1-0 | 1.000 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 2 | Sat Nov 8 | vs Bellarmine | W98-71 | 2-0 | 1.000 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 3 | Thu Nov 13 | vs California | W99-96 | 3-0 | 1.000 | - | CBSSN | Bramlage Coliseum · Manhattan, KS |
| 4 | Mon Nov 17 | vs Tulsa | W84-83 | 4-0 | 1.000 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 5 | Thu Nov 20 | vs Mississippi St | W98-77 | 5-0 | 1.000 | - | Peacock | Bramlage Coliseum · Manhattan, KS |
| 6 | Fri Nov 21 | at Nebraska | L85-86 | 5-1 | .833 | - | Peacock | Pinnacle Bank Arena · Lincoln, NE |
| 7 | Tue Nov 25 | at #25Indiana | L69-86 | 5-2 | .714 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
| 8 | Mon Dec 1 | vs Bowling Green | L66-82 | 5-3 | .625 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 9 | Sat Dec 6 | vs Seton Hall | L67-78 | 5-4 | .556 | - | ESPNU | Bramlage Coliseum · Manhattan, KS |
| 10 | Mon Dec 8 | vs Miss Valley St | W108-49 | 6-4 | .600 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 11 | Sat Dec 13 | at Creighton | W83-76 | 7-4 | .636 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 12 | Sat Dec 20 | vs South Dakota | W106-76 | 8-4 | .667 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 13 | Sun Dec 28 | vs UL Monroe | W94-85 | 9-4 | .692 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 14 | Sat Jan 3 | vs #10BYU | L73-83 | 9-5 | .643 | - | CBS | Bramlage Coliseum · Manhattan, KS |
| 15 | Wed Jan 7 | at #1Arizona | L76-101 | 9-6 | .600 | - | FS1 | McKale Center · Tucson, AZ |
| 16 | Sat Jan 10 | at Arizona St | L84-87 | 9-7 | .563 | - | Peacock | Desert Financial Arena · Tempe, AZ |
| 17 | Wed Jan 14 | vs UCF | L73-82 | 9-8 | .529 | - | Peacock | Bramlage Coliseum · Manhattan, KS |
| 18 | Sat Jan 17 | at Oklahoma St | L83-84 | 9-9 | .500 | - | CBSSN | Gallagher-Iba Arena · Stillwater, OK |
| 19 | Tue Jan 20 | vs Utah | W81-78 | 10-9 | .526 | - | CBSSN | Bramlage Coliseum · Manhattan, KS |
| 20 | Sat Jan 24 | vs #19Kansas | L62-86 | 10-10 | .500 | - | FOX | Bramlage Coliseum · Manhattan, KS |
| 21 | Tue Jan 27 | at West Virginia | L54-59 | 10-11 | .476 | - | FS1 | WVU Coliseum · Morgantown, WV |
| 22 | Sun Feb 1 | vs #8Iowa State | L61-95 | 10-12 | .455 | - | FOX | Bramlage Coliseum · Manhattan, KS |
| 23 | Sat Feb 7 | at TCU | L82-84 | 10-13 | .435 | - | TNT | Ed and Rae Schollmaier Arena · Fort Worth, TX |
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