| 1 | Wed Nov 5 | vs South Dakota | W92-76 | 1-0 | 1.000 | #23 | Peacock | CHI Health Center Omaha · Omaha, NE |
| 2 | Tue Nov 11 | at #19Gonzaga | L63-90 | 1-1 | .500 | #23 | ESPN | McCarthey Athletic Center · Spokane, WA |
| 3 | Fri Nov 14 | vs MD-Eastern | W84-45 | 2-1 | .667 | #23 | Peacock | CHI Health Center Omaha · Omaha, NE |
| 4 | Wed Nov 19 | vs North Dakota | W75-60 | 3-1 | .750 | - | ESPN+ | CHI Health Center Omaha · Omaha, NE |
| 5 | Mon Nov 24 | at Baylor | L74-81 | 3-2 | .600 | - | truTV | Ferrell Center · Waco, TX |
| 6 | Tue Nov 25 | at #15Iowa State | L60-78 | 3-3 | .500 | - | truTV | James H. Hilton Coliseum · Ames, IA |
| 7 | Thu Nov 27 | vs Oregon | W76-66 | 4-3 | .571 | - | truTV | CHI Health Center Omaha · Omaha, NE |
| 8 | Tue Dec 2 | vs Nicholls | W96-76 | 5-3 | .625 | - | truTV | CHI Health Center Omaha · Omaha, NE |
| 9 | Sun Dec 7 | at Nebraska | L50-71 | 5-4 | .556 | - | FS1 | Pinnacle Bank Arena · Lincoln, NE |
| 10 | Sat Dec 13 | vs Kansas St | L76-83 | 5-5 | .500 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 11 | Wed Dec 17 | at Xavier | W98-57 | 6-5 | .545 | - | FS1 | Cintas Center · Cincinnati, OH |
| 12 | Sat Dec 20 | vs Marquette | W84-63 | 7-5 | .583 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 13 | Mon Dec 22 | vs Utah Tech | W92-69 | 8-5 | .615 | - | ESPN+ | CHI Health Center Omaha · Omaha, NE |
| 14 | Tue Dec 30 | vs Butler | W89-85 | 9-5 | .643 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 15 | Sun Jan 4 | at Seton Hall | L54-56 | 9-6 | .600 | - | Peacock | Prudential Center · Newark, NJ |
| 16 | Wed Jan 7 | at Villanova | W76-72 | 10-6 | .625 | - | Peacock | Finneran Pavilion · Villanova, PA |
| 17 | Sat Jan 10 | vs St John's | L73-90 | 10-7 | .588 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 18 | Tue Jan 13 | vs Georgetown | W86-83 (OT) | 11-7 | .611 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 19 | Fri Jan 16 | at Providence | L88-93 | 11-8 | .579 | - | FS1 | Amica Mutual Pavilion · Providence, RI |
| 20 | Wed Jan 21 | vsXavier | W94-93 | 12-8 | .600 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 21 | Tue Jan 27 | atMarquette | L62-86 | 12-9 | .571 | - | TNT | Fiserv Forum · Milwaukee, WI |
| 22 | Sat Jan 31 | vs #2UConn | L58-85 | 12-10 | .545 | - | FOX | CHI Health Center Omaha · Omaha, NE |
| 23 | Wed Feb 4 | atGeorgetown | L68-76 | 12-11 | .522 | - | Peacock | Capital One Arena · Washington, D.C. |
| 24 | Sat Feb 7 | vsSeton Hall | W69-68 | 13-11 | .542 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
DePaul