| 1 | Mon Nov 3 | vs New Haven | W79-55 | 1-0 | 1.000 | #4 | ESPN+ | Gampel Pavilion · Storrs, CT |
| 2 | Fri Nov 7 | vs UMass Lowell | W110-47 | 2-0 | 1.000 | #4 | Peacock | Gampel Pavilion · Storrs, CT |
| 3 | Mon Nov 10 | vs Columbia | W89-62 | 3-0 | 1.000 | #3 | FS1 | Gampel Pavilion · Storrs, CT |
| 4 | Sat Nov 15 | vs #7BYU | W86-84 | 4-0 | 1.000 | #3 | FOX | Gampel Pavilion · Storrs, CT |
| 5 | Wed Nov 19 | vs #4Arizona | L67-71 | 4-1 | .800 | #3 | FS1 | Gampel Pavilion · Storrs, CT |
| 6 | Sun Nov 23 | vs Bryant | W72-49 | 5-1 | .833 | #3 | truTV | Gampel Pavilion · Storrs, CT |
| 7 | Fri Nov 28 | vs #13Illinois | W74-61 | 6-1 | .857 | #5 | FOX | Gampel Pavilion · Storrs, CT |
| 8 | Tue Dec 2 | at #21Kansas | W61-56 | 7-1 | .875 | #5 | ESPN2 | Allen Fieldhouse · Lawrence, KS |
| 9 | Fri Dec 5 | vs E Texas A&M | W83-59 | 8-1 | .889 | #5 | Peacock | Gampel Pavilion · Storrs, CT |
| 10 | Tue Dec 9 | vs #18Florida | W77-73 | 9-1 | .900 | #5 | ESPN | Gampel Pavilion · Storrs, CT |
| 11 | Fri Dec 12 | vs Texas | W71-63 | 10-1 | .909 | #5 | FOX | Gampel Pavilion · Storrs, CT |
| 12 | Tue Dec 16 | vs Butler | W79-60 | 11-1 | .917 | #5 | Peacock | Gampel Pavilion · Storrs, CT |
| 13 | Sun Dec 21 | at DePaul | W72-54 | 12-1 | .923 | #5 | FS1 | Wintrust Arena · Chicago, IL |
| 14 | Wed Dec 31 | at Xavier | W90-67 | 13-1 | .929 | #4 | Peacock | Cintas Center · Cincinnati, OH |
| 15 | Sun Jan 4 | vs Marquette | W73-57 | 14-1 | .933 | #4 | NBC | Gampel Pavilion · Storrs, CT |
| 16 | Wed Jan 7 | at Providence | W103-98 (OT) | 15-1 | .938 | #4 | Peacock | Amica Mutual Pavilion · Providence, RI |
| 17 | Sat Jan 10 | vsDePaul | W72-60 | 16-1 | .941 | #4 | TNT | Gampel Pavilion · Storrs, CT |
| 18 | Tue Jan 13 | at #25Seton Hall | W69-64 | 17-1 | .944 | #3 | truTV | Prudential Center · Newark, NJ |
| 19 | Sat Jan 17 | at Georgetown | W64-62 | 18-1 | .947 | #3 | FOX | Capital One Arena · Washington, D.C. |
| 20 | Sat Jan 24 | vs Villanova | W75-67 (OT) | 19-1 | .950 | #2 | FOX | Gampel Pavilion · Storrs, CT |
| 21 | Tue Jan 27 | vsProvidence | W87-81 | 20-1 | .952 | #2 | TNT | Gampel Pavilion · Storrs, CT |
| 22 | Sat Jan 31 | at Creighton | W85-58 | 21-1 | .955 | #2 | FOX | CHI Health Center Omaha · Omaha, NE |
| 23 | Tue Feb 3 | vsXavier | W92-60 | 22-1 | .957 | #3 | Peacock | Gampel Pavilion · Storrs, CT |
| 24 | Fri Feb 6 | at #22St John's | L72-81 | 22-2 | .917 | #3 | FOX | Carnesecca Arena · Queens, NY |
