| 1 | Mon Nov 3 | vs TBD | W107-55 | 1-0 | 1.000 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 2 | Fri Nov 7 | at #4UConn | L47-110 | 1-1 | .500 | - | Peacock | Gampel Pavilion · Storrs, CT |
| 3 | Mon Nov 10 | vs New Haven | L67-73 | 1-2 | .333 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 4 | Thu Nov 13 | at Columbia | L72-86 | 1-3 | .250 | - | ESPN+ | Francis S. Levien Gymnasium · New York, NY |
| 5 | Sun Nov 16 | at Wake Forest | L75-109 | 1-4 | .200 | - | ACC Extra | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 6 | Wed Nov 19 | at Bradley | L77-87 | 1-5 | .167 | - | ESPN+ | Carver Arena · Peoria, IL |
| 7 | Sat Nov 22 | at Saint Peter's | L66-68 | 1-6 | .143 | - | ESPN+ | Yanitelli Center · Jersey City, NJ |
| 8 | Wed Nov 26 | at Stonehill | W75-64 | 2-6 | .250 | - | | placeholder · sf, ca |
| 9 | Sat Nov 29 | vsTBD | W90-67 | 3-6 | .333 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 10 | Sat Dec 6 | at UMass | L60-80 | 3-7 | .300 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 11 | Wed Dec 10 | vsTBD | W122-73 | 4-7 | .364 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 12 | Sat Dec 13 | at Quinnipiac | L71-75 | 4-8 | .333 | - | ESPN+ | M&T Bank Arena · Hamden, CT |
| 13 | Tue Dec 16 | vs Sacred Heart | W87-82 | 5-8 | .385 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 14 | Sun Dec 21 | at Boston Univ | L76-88 | 5-9 | .357 | - | ESPN+ | Case Gym · Boston, MA |
| 15 | Mon Dec 29 | at #25Iowa | L62-90 | 5-10 | .333 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 16 | Sat Jan 3 | vs Albany | W83-71 | 6-10 | .375 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 17 | Thu Jan 8 | at Bryant | W77-63 | 7-10 | .412 | - | ESPN+ | Chace Athletic Center · Smithfield, RI |
| 18 | Sat Jan 10 | at Binghamton | W73-68 | 8-10 | .444 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 19 | Thu Jan 15 | vs NJIT | L64-73 | 8-11 | .421 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 20 | Thu Jan 22 | vs Vermont | L68-77 | 8-12 | .400 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 21 | Sat Jan 24 | at UMBC | L56-79 | 8-13 | .381 | - | ESPN+ | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 22 | Thu Jan 29 | at New Hampshire | L61-66 | 8-14 | .364 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 23 | Sat Jan 31 | vs Maine | W91-77 | 9-14 | .391 | - | ESPN+ | Costello Athletic Center · Lowell, MA |
| 24 | Thu Feb 5 | atNJIT | L56-81 | 9-15 | .375 | - | ESPN+ | NJIT Wellness and Events Center · Newark, NJ |
| 25 | Sat Feb 7 | atAlbany | W89-79 | 10-15 | .400 | - | ESPN+ | SEFCU Arena · Albany, NY |
