| 1 | Mon Nov 3 | at Syracuse | L47-85 | 0-1 | .000 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 2 | Wed Nov 5 | vs TBD | W66-56 | 1-1 | .500 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 3 | Sat Nov 8 | vs Niagara | L59-67 | 1-2 | .333 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 4 | Wed Nov 12 | at Georgetown | L70-83 | 1-3 | .250 | - | ESPN+ | Capital One Arena · Washington, D.C. |
| 5 | Sat Nov 15 | at Longwood | L82-90 | 1-4 | .200 | - | ESPN+ | Willett Hall · Farmville, VA |
| 6 | Wed Nov 19 | vsTBD | W69-58 | 2-4 | .333 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 7 | Sat Nov 22 | vs MD-Eastern | L52-63 | 2-5 | .286 | - | | Koessler Athletic Center · Buffalo, NY |
| 8 | Sun Nov 23 | at Canisius | L66-75 | 2-6 | .250 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 9 | Tue Dec 2 | vs Lehigh | W80-71 (OT) | 3-6 | .333 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 10 | Sat Dec 6 | vs Le Moyne | L63-78 | 3-7 | .300 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 11 | Sat Dec 13 | vs C Connecticut | L67-84 | 3-8 | .273 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 12 | Wed Dec 17 | at Pitt | L63-103 | 3-9 | .250 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 13 | Sat Dec 20 | at Mercyhurst | L61-82 | 3-10 | .231 | - | | Mercyhurst Athletic Center · Erie, PA |
| 14 | Tue Dec 23 | at Army | L85-95 (OT) | 3-11 | .214 | - | ESPN+ | Christl Arena · West Point, NY |
| 15 | Mon Dec 29 | vsTBD | W100-60 | 4-11 | .267 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 16 | Sat Jan 3 | vs NJIT | L65-73 | 4-12 | .250 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 17 | Thu Jan 8 | at Vermont | L59-60 | 4-13 | .235 | - | ESPN+ | Patrick Gymnasium · Burlington, VT |
| 18 | Sat Jan 10 | vs UMass Lowell | L68-73 | 4-14 | .222 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 19 | Thu Jan 15 | at Albany | L53-69 | 4-15 | .211 | - | ESPN+ | SEFCU Arena · Albany, NY |
| 20 | Mon Jan 19 | vs UMBC | L60-78 | 4-16 | .200 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 21 | Thu Jan 22 | at New Hampshire | L82-88 (3OT) | 4-17 | .190 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 22 | Sat Jan 24 | at Maine | L63-79 | 4-18 | .182 | - | ESPN+ | Cross Insurance Center · Bangor, ME |
| 23 | Thu Jan 29 | vs Bryant | W63-60 | 5-18 | .217 | - | ESPN+ | Events Center (Binghamton) · Binghamton, NY |
| 24 | Thu Feb 5 | atUMBC | L62-79 | 5-19 | .208 | - | ESPN+ | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 25 | Sat Feb 7 | atNJIT | L64-73 | 5-20 | .200 | - | ESPN+ | NJIT Wellness and Events Center · Newark, NJ |
