| 1 | Mon Nov 3 | vs Binghamton | W85-47 | 1-0 | 1.000 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 2 | Sat Nov 8 | vs Delaware St | W83-43 | 2-0 | 1.000 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 3 | Sat Nov 15 | vs Drexel | W80-50 | 3-0 | 1.000 | - | Peacock | JMA Wireless Dome · Syracuse, NY |
| 4 | Tue Nov 18 | vs Monmouth | W78-73 | 4-0 | 1.000 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 5 | Mon Nov 24 | at #3Houston | L74-78 (OT) | 4-1 | .800 | - | TNT | Fertitta Center · Houston, TX |
| 6 | Tue Nov 25 | at Kansas | L60-71 | 4-2 | .667 | - | TNT | Allen Fieldhouse · Lawrence, KS |
| 7 | Wed Nov 26 | at #15Iowa State | L64-95 | 4-3 | .571 | - | TNT | James H. Hilton Coliseum · Ames, IA |
| 8 | Tue Dec 2 | vs #13Tennessee | W62-60 | 5-3 | .625 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 9 | Thu Dec 11 | vs Saint Joseph's | W71-63 | 6-3 | .667 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 10 | Sat Dec 13 | vs Hofstra | L69-70 | 6-4 | .600 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 11 | Wed Dec 17 | vs Mercyhurst | W76-62 | 7-4 | .636 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 12 | Sat Dec 20 | vs Northeastern | W91-83 | 8-4 | .667 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 13 | Mon Dec 22 | vs Stonehill | W77-48 | 9-4 | .692 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 14 | Wed Dec 31 | vs Clemson | L61-64 | 9-5 | .643 | - | ESPN2 | JMA Wireless Dome · Syracuse, NY |
| 15 | Tue Jan 6 | at Georgia Tech | W82-72 | 10-5 | .667 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 16 | Sat Jan 10 | at Pitt | W83-72 | 11-5 | .688 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 17 | Tue Jan 13 | vs Florida St | W94-86 | 12-5 | .706 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 18 | Sat Jan 17 | at Boston College | L73-81 (OT) | 12-6 | .667 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 19 | Wed Jan 21 | vs Virginia Tech | L74-76 | 12-7 | .632 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 20 | Sat Jan 24 | vs Miami | L76-85 | 12-8 | .600 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 21 | Tue Jan 27 | at NC State | L68-88 | 12-9 | .571 | - | ESPNU | PNC Arena · Raleigh, NC |
| 22 | Sat Jan 31 | vs Notre Dame | W86-72 | 13-9 | .591 | - | The CW Network | JMA Wireless Dome · Syracuse, NY |
| 23 | Mon Feb 2 | at #14UNC | L77-87 | 13-10 | .565 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Sat Feb 7 | at #18Virginia | L59-72 | 13-11 | .542 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
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