| 1 | Mon Nov 3 | at Clemson | L38-88 | 0-1 | .000 | - | ACC Extra | Littlejohn Coliseum · Clemson, SC |
| 2 | Thu Nov 6 | vs TBD | W113-31 | 1-1 | .500 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 3 | Sun Nov 9 | at Harvard | L75-86 | 1-2 | .333 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 4 | Wed Nov 12 | vsTBD | W97-69 | 2-2 | .500 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 5 | Sat Nov 15 | at George Mason | L44-61 | 2-3 | .400 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 6 | Tue Nov 18 | at Providence | L66-98 | 2-4 | .333 | - | ESPN+ | Amica Mutual Pavilion · Providence, RI |
| 7 | Wed Nov 26 | vs Brown | L47-59 | 2-5 | .286 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 8 | Sun Nov 30 | at Fairfield | L68-72 | 2-6 | .250 | - | ESPN+ | Leo D. Mahoney Arena · Fairfield, CT |
| 9 | Wed Dec 3 | at Dartmouth | L68-69 | 2-7 | .222 | - | ESPN+ | Edward Leede Arena · Hanover, NH |
| 10 | Sat Dec 6 | vs Boston Univ | W88-82 (OT) | 3-7 | .300 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 11 | Wed Dec 17 | vs Stonehill | W59-58 | 4-7 | .364 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 12 | Sun Dec 21 | at Saint Louis | L79-93 | 4-8 | .333 | - | ESPN+ | Chaifetz Arena · St. Louis, MO |
| 13 | Tue Dec 30 | at #13Nebraska | L55-86 | 4-9 | .308 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 14 | Sat Jan 3 | vs Vermont | L61-80 | 4-10 | .286 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 15 | Thu Jan 8 | at NJIT | L76-80 | 4-11 | .267 | - | ESPN+ | NJIT Wellness and Events Center · Newark, NJ |
| 16 | Sat Jan 10 | at UMBC | L74-75 | 4-12 | .250 | - | ESPN+ | Chesapeake Employers Insurance Arena · Baltimore, MD |
| 17 | Mon Jan 19 | at Maine | W65-48 | 5-12 | .294 | - | ESPN+ | Cross Insurance Center · Bangor, ME |
| 18 | Thu Jan 22 | vs Binghamton | W88-82 (3OT) | 6-12 | .333 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 19 | Sat Jan 24 | vs Albany | W80-72 | 7-12 | .368 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 20 | Thu Jan 29 | vs UMass Lowell | W66-61 | 8-12 | .400 | - | ESPN+ | Lundholm Gymnasium · Durham, NH |
| 21 | Sat Jan 31 | at Bryant | L84-92 | 8-13 | .381 | - | ESPN+ | Chace Athletic Center · Smithfield, RI |
| 22 | Sat Feb 7 | atVermont | L57-80 | 8-14 | .364 | - | ESPN+ | Patrick Gymnasium · Burlington, VT |
