| 1 | Mon Nov 3 | vs Marist | W66-62 | 1-0 | 1.000 | - | ESPN+ | Cintas Center · Cincinnati, OH |
| 2 | Thu Nov 6 | vs Le Moyne | W74-69 | 2-0 | 1.000 | - | ESPN+ | Cintas Center · Cincinnati, OH |
| 3 | Mon Nov 10 | vs Santa Clara | L68-87 | 2-1 | .667 | - | FS1 | Cintas Center · Cincinnati, OH |
| 4 | Fri Nov 14 | at Iowa | L62-81 | 2-2 | .500 | - | FS1 | Carver-Hawkeye Arena · Iowa City, IA |
| 5 | Tue Nov 18 | vs Old Dominion | W99-69 | 3-2 | .600 | - | ESPN+ | Cintas Center · Cincinnati, OH |
| 6 | Fri Nov 21 | vs Georgia | L77-78 | 3-3 | .500 | - | ESPN2 | TD Arena · Charleston, SC |
| 7 | Sun Nov 23 | vs West Virginia | W78-68 | 4-3 | .571 | - | ESPN | TD Arena · Charleston, SC |
| 8 | Fri Nov 28 | vs Texas A&M-CC | W88-67 | 5-3 | .625 | - | ESPN+ | Cintas Center · Cincinnati, OH |
| 9 | Mon Dec 1 | vs St Francis PA | W96-74 | 6-3 | .667 | - | truTV | Cintas Center · Cincinnati, OH |
| 10 | Fri Dec 5 | vs Cincinnati | W79-74 | 7-3 | .700 | - | TNT | Cintas Center · Cincinnati, OH |
| 11 | Fri Dec 12 | vs Missouri St | W75-57 | 8-3 | .727 | - | truTV | Cintas Center · Cincinnati, OH |
| 12 | Wed Dec 17 | vs Creighton | L57-98 | 8-4 | .667 | - | FS1 | Cintas Center · Cincinnati, OH |
| 13 | Sat Dec 20 | at Georgetown | W80-77 | 9-4 | .692 | - | FS1 | Capital One Arena · Washington, D.C. |
| 14 | Wed Dec 31 | vs #4UConn | L67-90 | 9-5 | .643 | - | Peacock | Cintas Center · Cincinnati, OH |
| 15 | Sat Jan 3 | at DePaul | L77-86 | 9-6 | .600 | - | FS1 | Wintrust Arena · Chicago, IL |
| 16 | Wed Jan 7 | at Marquette | L65-66 | 9-7 | .563 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 17 | Sat Jan 10 | vs Providence | W97-84 | 10-7 | .588 | - | FS1 | Cintas Center · Cincinnati, OH |
| 18 | Wed Jan 14 | vs Butler | W89-75 | 11-7 | .611 | - | FS1 | Cintas Center · Cincinnati, OH |
| 19 | Wed Jan 21 | atCreighton | L93-94 | 11-8 | .579 | - | FS1 | CHI Health Center Omaha · Omaha, NE |
| 20 | Sat Jan 24 | vs St John's | L83-88 | 11-9 | .550 | - | truTV | Cintas Center · Cincinnati, OH |
| 21 | Wed Jan 28 | at Seton Hall | L68-86 | 11-10 | .524 | - | Peacock | Prudential Center · Newark, NJ |
| 22 | Sat Jan 31 | vsDePaul | W68-66 | 12-10 | .545 | - | FS1 | Cintas Center · Cincinnati, OH |
| 23 | Tue Feb 3 | at#3UConn | L60-92 | 12-11 | .522 | - | Peacock | Gampel Pavilion · Storrs, CT |
| 24 | Mon Feb 9 | at#17St John's | L82-87 (OT) | 12-12 | .500 | - | FS1 | Carnesecca Arena · Queens, NY |
Villanova