| 1 | Mon Nov 3 | vs W Carolina | W94-63 | 1-0 | 1.000 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 2 | Fri Nov 7 | vs Georgia St | W74-64 | 2-0 | 1.000 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 3 | Tue Nov 11 | vs Dayton | W74-62 | 3-0 | 1.000 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 4 | Sun Nov 16 | vs Mount St Mary | W72-55 | 4-0 | 1.000 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 5 | Fri Nov 21 | vs #6Louisville | L64-74 | 4-1 | .800 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 6 | Mon Nov 24 | vs NJIT | W94-67 | 5-1 | .833 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 7 | Wed Nov 26 | vs E Michigan | L56-64 | 5-2 | .714 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 8 | Mon Dec 1 | vs Tarleton | W76-58 | 6-2 | .750 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 9 | Fri Dec 5 | at Xavier | L74-79 | 6-3 | .667 | - | TNT | Cintas Center · Cincinnati, OH |
| 10 | Sat Dec 13 | at Georgia | L65-84 | 6-4 | .600 | - | ESPNU | State Farm Arena · Atlanta, GA |
| 11 | Wed Dec 17 | vs Alabama St | W88-51 | 7-4 | .636 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 12 | Sun Dec 21 | at Clemson | L65-68 | 7-5 | .583 | - | ESPN | Littlejohn Coliseum · Clemson, SC |
| 13 | Mon Dec 29 | vs Lipscomb | W89-62 | 8-5 | .615 | - | ESPN+ | Fifth Third Arena · Cincinnati, OH |
| 14 | Sat Jan 3 | vs #8Houston | L60-67 | 8-6 | .571 | - | FOX | Fifth Third Arena · Cincinnati, OH |
| 15 | Tue Jan 6 | at West Virginia | L60-62 | 8-7 | .533 | - | ESPN2 | WVU Coliseum · Morgantown, WV |
| 16 | Sun Jan 11 | at #25UCF | L72-73 | 8-8 | .500 | - | ESPN2 | Addition Financial Arena · Orlando, FL |
| 17 | Wed Jan 14 | vs Colorado | W77-68 | 9-8 | .529 | - | Peacock | Fifth Third Arena · Cincinnati, OH |
| 18 | Sat Jan 17 | vs #2Iowa State | W79-70 | 10-8 | .556 | - | Peacock | Fifth Third Arena · Cincinnati, OH |
| 19 | Wed Jan 21 | at #1Arizona | L51-77 | 10-9 | .526 | - | FS1 | McKale Center · Tucson, AZ |
| 20 | Sat Jan 24 | at Arizona St | L68-82 | 10-10 | .500 | - | CBSSN | Desert Financial Arena · Tempe, AZ |
| 21 | Wed Jan 28 | vs Baylor | W67-57 | 11-10 | .524 | - | FS1 | Fifth Third Arena · Cincinnati, OH |
| 22 | Sat Jan 31 | at#10Houston | L54-76 | 11-11 | .500 | - | FOX | Fertitta Center · Houston, TX |
| 23 | Thu Feb 5 | vsWest Virginia | L54-59 | 11-12 | .478 | - | ESPN2 | Fifth Third Arena · Cincinnati, OH |
| 24 | Sun Feb 8 | vsUCF | W92-72 | 12-12 | .500 | - | CBSSN | Fifth Third Arena · Cincinnati, OH |
Kansas St
Utah
#9Kansas
#16Texas Tech
Oklahoma St
#22BYU
TCU