| 1 | Mon Nov 3 | vs Montana St | W84-78 | 1-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 2 | Sat Nov 8 | vs E Washington | W102-97 (OT) | 2-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 3 | Fri Nov 14 | vs Providence | W97-88 | 3-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 4 | Mon Nov 17 | vs Alabama St | W94-66 | 4-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 5 | Fri Nov 21 | vs UC Davis | W95-79 | 5-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 6 | Thu Nov 27 | vs San Francisco | W79-69 | 6-0 | 1.000 | - | CBSSN | CU Events Center · Boulder, CO |
| 7 | Fri Nov 28 | vs Washington | W81-68 | 7-0 | 1.000 | - | truTV | CU Events Center · Boulder, CO |
| 8 | Mon Dec 1 | vs CA Baptist | W78-70 | 8-0 | 1.000 | - | ESPN+ | CU Events Center · Boulder, CO |
| 9 | Sat Dec 6 | at Colorado St | L86-91 | 8-1 | .889 | - | CBSSN | Moby Arena · Fort Collins, CO |
| 10 | Sat Dec 13 | vs UTSA | W88-64 | 9-1 | .900 | - | ESPN+ | CU Events Center · Boulder, CO |
| 11 | Wed Dec 17 | vs Portland St | W84-73 | 10-1 | .909 | - | ESPN+ | CU Events Center · Boulder, CO |
| 12 | Sat Dec 20 | vs Stanford | L68-77 | 10-2 | .833 | - | ESPNU | Mortgage Matchup Center · Phoenix, AZ |
| 13 | Sun Dec 28 | vs N Colorado | L81-86 | 10-3 | .769 | - | ESPN+ | CU Events Center · Boulder, CO |
| 14 | Sat Jan 3 | at Arizona St | W95-89 | 11-3 | .786 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 15 | Wed Jan 7 | vs Utah | W85-73 | 12-3 | .800 | - | ESPN+ | CU Events Center · Boulder, CO |
| 16 | Sat Jan 10 | vs #14Texas Tech | L71-73 | 12-4 | .750 | - | CBSSN | CU Events Center · Boulder, CO |
| 17 | Wed Jan 14 | at Cincinnati | L68-77 | 12-5 | .706 | - | Peacock | Fifth Third Arena · Cincinnati, OH |
| 18 | Sat Jan 17 | at West Virginia | L61-72 | 12-6 | .667 | - | CBSSN | WVU Coliseum · Morgantown, WV |
| 19 | Tue Jan 20 | vs #19Kansas | L69-75 | 12-7 | .632 | - | ESPN | CU Events Center · Boulder, CO |
| 20 | Sat Jan 24 | vs UCF | L86-95 | 12-8 | .600 | - | ESPN+ | CU Events Center · Boulder, CO |
| 21 | Thu Jan 29 | at #8Iowa State | L67-97 | 12-9 | .571 | - | FS1 | James H. Hilton Coliseum · Ames, IA |
| 22 | Sun Feb 1 | vs TCU | W87-61 | 13-9 | .591 | - | TNT | CU Events Center · Boulder, CO |
| 23 | Wed Feb 4 | at Baylor | L67-86 | 13-10 | .565 | - | Peacock | Ferrell Center · Waco, TX |
| 24 | Sat Feb 7 | vsArizona St | W78-70 | 14-10 | .583 | - | ESPN2 | CU Events Center · Boulder, CO |
#22BYU
Oklahoma St
Kansas St
#3Houston
#1Arizona