| 1 | Wed Nov 5 | vs TBD | W97-30 | 1-0 | 1.000 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 2 | Fri Nov 7 | vs SIUE | L60-77 | 1-1 | .500 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 3 | Wed Nov 12 | at Texas St | L69-80 | 1-2 | .333 | - | ESPN+ | Strahan Arena · San Marcos, TX |
| 4 | Sat Nov 15 | at Denver | W84-79 | 2-2 | .500 | - | | Hamilton Gymnasium · Denver, CO |
| 5 | Tue Nov 18 | vsTBD | W103-70 | 3-2 | .600 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 6 | Mon Nov 24 | at Abilene Chrstn | L50-61 | 3-3 | .500 | - | | Moody Coliseum (Abilene) · Abilene, TX |
| 7 | Tue Nov 25 | at Georgia So | W77-64 | 4-3 | .571 | - | | W.S. Hanner Fieldhouse · Statesboro, GA |
| 8 | Sun Nov 30 | vs South Alabama | L58-82 | 4-4 | .500 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 9 | Sun Dec 7 | at #12Alabama | L55-97 | 4-5 | .444 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 10 | Sat Dec 13 | at Colorado | L64-88 | 4-6 | .400 | - | ESPN+ | CU Events Center · Boulder, CO |
| 11 | Wed Dec 17 | at USC | L70-97 | 4-7 | .364 | - | BTN | Galen Center · Los Angeles, CA |
| 12 | Mon Dec 22 | vs Seattle U | L68-71 | 4-8 | .333 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 13 | Wed Dec 31 | at FAU | L70-110 | 4-9 | .308 | - | ESPN+ | FAU Arena · Boca Raton, FL |
| 14 | Sat Jan 3 | at Temple | L57-76 | 4-10 | .286 | - | ESPNU | Liacouras Center · Philadelphia, PA |
| 15 | Wed Jan 7 | vs Charlotte | L58-74 | 4-11 | .267 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 16 | Sat Jan 10 | vs Tulane | L52-85 | 4-12 | .250 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 17 | Wed Jan 14 | vs Rice | L73-89 | 4-13 | .235 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 18 | Sun Jan 18 | at Memphis | L69-95 | 4-14 | .222 | - | ESPNU | FedExForum · Memphis, TN |
| 19 | Wed Jan 21 | at North Texas | L62-81 | 4-15 | .211 | - | ESPN+ | The Super Pit · Denton, TX |
| 20 | Sat Jan 24 | vsTemple | L64-70 | 4-16 | .200 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 21 | Wed Jan 28 | vs UAB | L73-83 | 4-17 | .190 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 22 | Wed Feb 4 | at South Florida | L88-109 | 4-18 | .182 | - | ESPN+ | Yuengling Center · Tampa, FL |
| 23 | Sat Feb 7 | vsNorth Texas | L58-81 | 4-19 | .174 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
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