| 1 | Tue Nov 4 | vs TBD | W119-50 | 1-0 | 1.000 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 2 | Fri Nov 7 | at UTSA | W77-60 | 2-0 | 1.000 | - | ESPN+ | UTSA Convocation Center · San Antonio, TX |
| 3 | Mon Nov 10 | vs Indiana St | L55-64 | 2-1 | .667 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 4 | Fri Nov 14 | at Drake | W61-59 | 3-1 | .750 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 5 | Mon Nov 17 | at #23Wisconsin | L69-94 | 3-2 | .600 | - | BTN | Kohl Center · Madison, WI |
| 6 | Fri Nov 21 | at Air Force | L63-77 | 3-3 | .500 | - | | Clune Arena · Colorado Springs, CO |
| 7 | Sun Nov 23 | vs Alabama St | W83-68 | 4-3 | .571 | - | | Clune Arena · Colorado Springs, CO |
| 8 | Fri Nov 28 | vsTBD | W92-55 | 5-3 | .625 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 9 | Tue Dec 2 | at North Florida | W72-63 | 6-3 | .667 | - | ESPN+ | UNF Arena · Jacksonville, FL |
| 10 | Sat Dec 6 | vs W Michigan | L73-83 | 6-4 | .600 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 11 | Sun Dec 14 | vsTBD | W97-54 | 7-4 | .636 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 12 | Thu Dec 18 | at E Illinois | L72-76 (OT) | 7-5 | .583 | - | ESPN+ | Lantz Arena · Charleston, IL |
| 13 | Mon Dec 22 | at W Illinois | W66-61 | 8-5 | .615 | - | ESPN+ | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 14 | Thu Jan 1 | vs So Indiana | W59-55 | 9-5 | .643 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 15 | Sat Jan 3 | vs Morehead St | L72-73 | 9-6 | .600 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 16 | Tue Jan 6 | vs Lindenwood | W66-62 | 10-6 | .625 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 17 | Thu Jan 8 | vs Little Rock | L70-73 | 10-7 | .588 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 18 | Thu Jan 15 | at UT Martin | L59-65 | 10-8 | .556 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 19 | Sat Jan 17 | at SE Missouri St | W68-55 | 11-8 | .579 | - | ESPN+ | Show Me Center · Cape Girardeau, MO |
| 20 | Thu Jan 22 | vs Tennessee St | W74-66 | 12-8 | .600 | - | ESPNU | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 21 | Sat Jan 24 | vs Tennessee Tech | W62-58 | 13-8 | .619 | - | ESPN+ | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 22 | Thu Jan 29 | atMorehead St | L65-67 | 13-9 | .591 | - | ESPN+ | Ellis T. Johnson Arena · Morehead, KY |
| 23 | Sat Jan 31 | atSo Indiana | W58-46 | 14-9 | .609 | - | ESPN+ | Screaming Eagles Arena · Evansville, IN |
| 24 | Tue Feb 3 | atLindenwood | W78-72 | 15-9 | .625 | - | ESPN+ | placeholder · sf, ca |
| 25 | Sat Feb 7 | atLittle Rock | W71-61 | 16-9 | .640 | - | ESPN+ | Jack Stephens Center · Little Rock, AR |
