| 1 | Tue Nov 4 | vs Southern Utah | W81-64 | 1-0 | 1.000 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 2 | Sun Nov 9 | vs Utah Tech | W81-66 | 2-0 | 1.000 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 3 | Fri Nov 14 | vs #19Gonzaga | L65-77 | 2-1 | .667 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 4 | Mon Nov 17 | vs Georgia St | W75-62 | 3-1 | .750 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 5 | Thu Nov 20 | at Hawai'i | W83-76 | 4-1 | .800 | - | ESPN+ | Stan Sheriff Center · Honolulu, HI |
| 6 | Mon Nov 24 | at Texas | W87-86 | 5-1 | .833 | - | ESPN2 | Moody Center · Austin, TX |
| 7 | Tue Nov 25 | vs Washington St | W100-94 | 6-1 | .857 | - | ESPN | Desert Financial Arena · Tempe, AZ |
| 8 | Wed Nov 26 | vs USC | L75-88 | 6-2 | .750 | - | ESPN | Desert Financial Arena · Tempe, AZ |
| 9 | Sat Dec 6 | vs Oklahoma | W86-70 | 7-2 | .778 | - | CBSSN | Mortgage Matchup Center · Phoenix, AZ |
| 10 | Tue Dec 9 | vs N Arizona | W73-48 | 8-2 | .800 | - | ESPN+ | Desert Financial Arena · Tempe, AZ |
| 11 | Sat Dec 13 | at Santa Clara | W82-79 | 9-2 | .818 | - | TNT | Leavey Center · Santa Clara, CA |
| 12 | Wed Dec 17 | at UCLA | L77-90 | 9-3 | .750 | - | FS1 | Pauley Pavilion · Los Angeles, CA |
| 13 | Sun Dec 21 | vs Oregon St | L75-78 | 9-4 | .692 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 14 | Sat Jan 3 | vs Colorado | L89-95 | 9-5 | .643 | - | ESPN2 | Desert Financial Arena · Tempe, AZ |
| 15 | Wed Jan 7 | at #9BYU | L76-104 | 9-6 | .600 | - | Peacock | Marriott Center · Provo, UT |
| 16 | Sat Jan 10 | vs Kansas St | W87-84 | 10-6 | .625 | - | Peacock | Desert Financial Arena · Tempe, AZ |
| 17 | Wed Jan 14 | at #1Arizona | L82-89 | 10-7 | .588 | - | FS1 | McKale Center · Tucson, AZ |
| 18 | Sun Jan 18 | at #7Houston | L73-103 | 10-8 | .556 | - | ESPN | Fertitta Center · Houston, TX |
| 19 | Wed Jan 21 | vs West Virginia | L63-75 | 10-9 | .526 | - | Peacock | Desert Financial Arena · Tempe, AZ |
| 20 | Sat Jan 24 | vs Cincinnati | W82-68 | 11-9 | .550 | - | CBSSN | Desert Financial Arena · Tempe, AZ |
| 21 | Tue Jan 27 | at UCF | L76-79 | 11-10 | .524 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 22 | Sat Jan 31 | vs#1Arizona | L74-87 | 11-11 | .500 | - | TNT | Desert Financial Arena · Tempe, AZ |
| 23 | Wed Feb 4 | at Utah | W71-63 | 12-11 | .522 | - | CBSSN | Jon M. Huntsman Center · Salt Lake City, UT |
| 24 | Sat Feb 7 | atColorado | L70-78 | 12-12 | .500 | - | ESPN2 | CU Events Center · Boulder, CO |
Oklahoma St
#16Texas Tech
Baylor
TCU
#9Kansas
#5Iowa State