| 1 | Tue Nov 4 | vs Hawai'i | W60-59 | 1-0 | 1.000 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 2 | Fri Nov 7 | vs Rice | W67-63 | 2-0 | 1.000 | - | B1G+ | Matthew Knight Arena · Eugene, OR |
| 3 | Wed Nov 12 | vs S Dakota St | W83-69 | 3-0 | 1.000 | - | Peacock | Matthew Knight Arena · Eugene, OR |
| 4 | Mon Nov 17 | vs Oregon St | W87-75 | 4-0 | 1.000 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 5 | Mon Nov 24 | vs #21Auburn | L73-84 | 4-1 | .800 | - | truTV | Matthew Knight Arena · Eugene, OR |
| 6 | Tue Nov 25 | vs SDSU | L80-97 | 4-2 | .667 | - | TNT | Matthew Knight Arena · Eugene, OR |
| 7 | Thu Nov 27 | at Creighton | L66-76 | 4-3 | .571 | - | truTV | CHI Health Center Omaha · Omaha, NE |
| 8 | Tue Dec 2 | vs #24USC | L77-82 | 4-4 | .500 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 9 | Sat Dec 6 | at UCLA | L63-74 | 4-5 | .444 | - | Peacock | Pauley Pavilion · Los Angeles, CA |
| 10 | Sat Dec 13 | vs UC Davis | W104-62 | 5-5 | .500 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 11 | Wed Dec 17 | vs Portland | W94-69 | 6-5 | .545 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 12 | Sun Dec 21 | vs #7Gonzaga | L82-91 | 6-6 | .500 | - | Peacock | Matthew Knight Arena · Eugene, OR |
| 13 | Sun Dec 28 | vs Omaha | W80-57 | 7-6 | .538 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 14 | Fri Jan 2 | at Maryland | W64-54 | 8-6 | .571 | - | Peacock | XFINITY Center · College Park, MD |
| 15 | Mon Jan 5 | at Rutgers | L85-88 (OT) | 8-7 | .533 | - | Peacock | Jersey Mike’s Arena · Piscataway, NJ |
| 16 | Thu Jan 8 | vs Ohio State | L62-72 | 8-8 | .500 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 17 | Tue Jan 13 | at #8Nebraska | L55-90 | 8-9 | .471 | - | BTN | Pinnacle Bank Arena · Lincoln, NE |
| 18 | Sat Jan 17 | vs #4Michigan | L71-81 | 8-10 | .444 | - | NBC | Matthew Knight Arena · Eugene, OR |
| 19 | Tue Jan 20 | vs #10Michigan St | L52-68 | 8-11 | .421 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 20 | Sun Jan 25 | at Washington | L57-72 | 8-12 | .400 | - | Peacock | Alaska Airlines Arena · Seattle, WA |
| 21 | Wed Jan 28 | vsUCLA | L57-73 | 8-13 | .381 | - | BTN | Matthew Knight Arena · Eugene, OR |
| 22 | Sun Feb 1 | vs Iowa | L66-84 | 8-14 | .364 | - | FS1 | Matthew Knight Arena · Eugene, OR |
| 23 | Sat Feb 7 | at #12Purdue | L64-68 | 8-15 | .348 | - | CBS | Mackey Arena · West Lafayette, IN |
| 24 | Mon Feb 9 | at Indiana | L74-92 | 8-16 | .333 | - | FS1 | Simon Skjodt Assembly Hall · Bloomington, IN |
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