| 1 | Tue Nov 4 | vs Evansville | W82-51 | 1-0 | 1.000 | #1 | BTN | Mackey Arena · West Lafayette, IN |
| 2 | Fri Nov 7 | vs Oakland | W87-77 | 2-0 | 1.000 | #1 | Peacock | Mackey Arena · West Lafayette, IN |
| 3 | Thu Nov 13 | at #8Alabama | W87-80 | 3-0 | 1.000 | #2 | ESPN2 | Coleman Coliseum · Tuscaloosa, AL |
| 4 | Sun Nov 16 | vs Akron | W97-79 | 4-0 | 1.000 | #2 | BTN | Mackey Arena · West Lafayette, IN |
| 5 | Thu Nov 20 | vs Memphis | W80-71 | 5-0 | 1.000 | #1 | CBSSN | Mackey Arena · West Lafayette, IN |
| 6 | Fri Nov 21 | vs #15Texas Tech | W86-56 | 6-0 | 1.000 | #1 | CBSSN | Mackey Arena · West Lafayette, IN |
| 7 | Fri Nov 28 | vs E Illinois | W109-62 | 7-0 | 1.000 | #1 | BTN | Mackey Arena · West Lafayette, IN |
| 8 | Tue Dec 2 | at Rutgers | W81-65 | 8-0 | 1.000 | #1 | FS1 | Jersey Mike’s Arena · Piscataway, NJ |
| 9 | Sat Dec 6 | vs #10Iowa State | L58-81 | 8-1 | .889 | #1 | CBS | Mackey Arena · West Lafayette, IN |
| 10 | Wed Dec 10 | vs Minnesota | W85-57 | 9-1 | .900 | #6 | BTN | Mackey Arena · West Lafayette, IN |
| 11 | Sat Dec 13 | vs Marquette | W79-59 | 10-1 | .909 | #6 | Peacock | Mackey Arena · West Lafayette, IN |
| 12 | Sat Dec 20 | vs #21Auburn | W88-60 | 11-1 | .917 | #6 | Peacock | Mackey Arena · West Lafayette, IN |
| 13 | Mon Dec 29 | vs Kent State | W101-60 | 12-1 | .923 | #5 | B1G+ | Mackey Arena · West Lafayette, IN |
| 14 | Sat Jan 3 | at Wisconsin | W89-73 | 13-1 | .929 | #5 | FOX | Kohl Center · Madison, WI |
| 15 | Wed Jan 7 | vs Washington | W81-73 | 14-1 | .933 | #5 | BTN | Mackey Arena · West Lafayette, IN |
| 16 | Sat Jan 10 | vs Penn State | W93-85 | 15-1 | .938 | #5 | BTN | Mackey Arena · West Lafayette, IN |
| 17 | Wed Jan 14 | vs Iowa | W79-72 | 16-1 | .941 | #5 | BTN | Mackey Arena · West Lafayette, IN |
| 18 | Sat Jan 17 | at USC | W69-64 | 17-1 | .944 | #5 | Peacock | Galen Center · Los Angeles, CA |
| 19 | Tue Jan 20 | at UCLA | L67-69 | 17-2 | .895 | #4 | Peacock | Pauley Pavilion · Los Angeles, CA |
| 20 | Sat Jan 24 | vs #11Illinois | L82-88 | 17-3 | .850 | #4 | FOX | Mackey Arena · West Lafayette, IN |
| 21 | Tue Jan 27 | at Indiana | L67-72 | 17-4 | .810 | #12 | Peacock | Simon Skjodt Assembly Hall · Bloomington, IN |
| 22 | Sun Feb 1 | at Maryland | W93-63 | 18-4 | .818 | #12 | CBS | XFINITY Center · College Park, MD |
| 23 | Sat Feb 7 | vs Oregon | W68-64 | 19-4 | .826 | #12 | CBS | Mackey Arena · West Lafayette, IN |
#7Nebraska
#2Michigan
#10Michigan St
Ohio State
Northwestern